New onset of myasthenia gravis after intravesical Bacillus Calmette-Guerin: A case report and literature review
We present a case involving the new onset of MG, in which the symptoms started shortly after intravesical Bacillus Calmette-Guerin (BCG) for bladder cancer.
Patient concerns:
A 69-year-old male with bladder cancer developed ptosis and diplopia 4 days after the completion of a treatment regimen with intravesical BCG weekly for 6 weeks.
Diagnoses:
Ocular MG was confirmed by a positive serum anti-acetylcholine receptor antibody test.
Interventions:
Treatment with high-dose methylprednisolone pulse therapy was given, after insufficient treatment with pyridostigmine bromide and 10 mg/d prednisolone.
Outcomes:
Symptoms resolved completely 12 days after high-dose methylprednisolone pulse therapy.
Lessons:
Intravesical BCG could be listed as a novel drug that may induce a new onset of MG along with drugs such as D-penicillamine and immune checkpoint inhibitors.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
More News: Bladder Cancer | Cancer | Cancer & Oncology | Immunotherapy | Lessons | Methylprednisolone | Myasthenia Gravis | Prednisolone