Optogenetic Therapies Move Closer to Clinical Use

With a clinical trial underway to restore vision optogenetically, researchers also see promise in using the technique to treat deafness, pain, and other conditions.
Source: The Scientist - Category: Science Tags: News & Opinion,News Analysis,The Scientist Source Type: news

Related Links:

Xu Zhao1, Zhi-qiang Zhou2, Ying Xiong1, Xu Chen3, Ke Xu4, Juan Li1, Ying Hu1, Xiao-long Peng1 and Wen-zhen Zhu1* 1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 3Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science an...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: While this study suggests that target size may have a statistically significant impact on the vHIT saccade profile of normal subjects, age has a greater influence on the incidence and size of small vHIT saccades. Introduction The video head impulse test (vHIT) is a quantitative adaptation of the clinical head impulse test (1), and enables functional assessment of the high-frequency angular vestibulo-ocular reflex (VOR) in all three planes of head rotation (2, 3). Lightweight goggles worn by the subject detect head movement using an accelerometer and gyroscope, and a high frame rate video camera tracks eye...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
(Michigan Medicine - University of Michigan) People under age 50 with hearing loss misuse prescription opioids at twice the rate of their hearing peers, and are also more likely to misuse alcohol and other drugs, a new national study finds. This means that health care providers may need to take special care when treating pain and mental health conditions in deaf and hard-of-hearing young adults, the researchers say.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
A person should not be defined by an illness or condition.  Often in popular media or casual conversation, people speak about the subject of a news story or an acquaintance by saying, “he is bipolar”, “schizophrenic”, or “mentally ill.” No one says, “She is cancer,” “she is a heart condition,” or “she is lupus.” Aside from a few very select common physical illnesses, such as diabetes where people find community and comfort in sharing their diagnosis, we would never consider insulting a person by simply identifying them by the disease which they ha...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Mental Health and Wellness Minding the Media Stigma Crisis Counseling destigmatization discrimination Labels neurodivergent Stereotypes Validation Source Type: blogs
ConclusionSickle cell disease can be diagnosed by newborn screening but, as in this case, may have a delayed presentation. The delay in diagnosis of homozygous sickle cell disease illustrates that other genetic disorders should be considered in patients who already have a diagnosis of one Mendelian disorder but show atypical features.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
ObjectivesTo compare the hearing performance of patients with conductive and mild mixed hearing loss and single ‐sided sensorineural deafness provided with a new transcutaneous bone conduction hearing implant (the Baha Attract System) with unaided hearing as well as aided with a sound processor on a softband. Furthermore, to evaluate safety and subjective benefit before and after implantation of the test de vice.ParticipantsFifty ‐four adult patients in five participating centres were enrolled in this prospective study. Baseline data were collected during a pre‐operative visit, and after a softband trial, all patient...
Source: Clinical Otolaryngology - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 6 October 2018Source: PM&RAuthor(s): John W. Norbury, Eric J. MorrisonAbstractThis is a case of 52-year old deaf female who was referred to the electrodiagnostic (EDX) laboratory for evaluation of pain and parasthesias in the left upper limb. The EDX study was normal. However, ultrasound revealed tendinopathy of the palmaris longus tendon, manifested by increased hypoechogenecity, caliber, and tenderness to sonopalpation compared to the right side. To the authors’ knowledge there are no reported cases of palmaris longus tendinopathy diagnosed with ultrasound. This case supports the ...
Source: PMandR - Category: Rehabilitation Source Type: research
Phumeza Tisile is a student at the University of Cape Town and an advocate working to help eradicate TBBy Phumeza TisileCAPE TOWN, Oct 3 2018 (IPS)Like death, hearing loss is irreversible. I never imagined that I would have to choose between the two until seven years ago when I became infected with tuberculosis (TB), a contagious disease caused by an airborne bacterium. TB is curable, but some strains are resistant to first line treatment, which can be the beginning of a nightmare for the infected person, as I found out in 2010. I was in the first year of undergraduate studies at the Cape Peninsula University of Technology...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health Population Poverty & SDGs TerraViva United Nations Source Type: news
This study investigated touch awareness when the brain was already focusing on a touch task. But there’s evidence from earlier work that, for inattentional effects to occur, the two stimuli do not have to involve the same senses, and the new paper in Psychological Science on inattentional anosmia also finds this.  Charles Spence, head of the Crossmodal Research Laboratory at the University of Oxford, and Sophie Forster at the University of Sussex, looked at the effects of performing a high vs. low attentional-load visual task on scent awareness.  Across a series of experiments, groups of participants had to...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Cognition Perception Source Type: blogs
More News: Audiology | Clinical Trials | Deafness | Opthalmology | Pain | Science