Triple-Negative Breast Cancer, Stem Cells, and African Ancestry.

Triple-Negative Breast Cancer, Stem Cells, and African Ancestry. Am J Pathol. 2017 Nov 11;: Authors: Jiagge E, Chitale D, Newman LA Abstract Triple-negative breast cancers (TNBC) are more common among African ancestry populations, such as African Americans and western, sub-Saharan Africans, compared to European ancestry populations. This phenotype prevalence contributes to breast cancer outcome disparities between African Americans and Caucasian Americans. Breast cancer stem cells represent the tumor subpopulation responsible for metastatic virulence and ongoing research seeks to characterize the extent to which TNBC versus non-TNBC stem cells may differ. This review summarizes the existing literature regarding TNBC and stem cells as they pertain to the breast cancer burden of African ancestry populations. Additional research related to variation in somatic tumor genomics between African American and Caucasian American is also summarized. This review furthermore explores the history of insights regarding breast cancer disparities related to racial-ethnic identity, socioeconomic status, and tumor biology. PMID: 29137951 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research