Organometallic ruthenium(II) complexes containing NS donor Schiff bases: Synthesis, structure, electrochemistry, DNA/BSA binding, DNA cleavage, radical scavenging and antibacterial activities

Publication date: 1 January 2018 Source:Journal of Organometallic Chemistry, Volume 854 Author(s): G. Devagi, F. Dallemer, P. Kalaivani, R. Prabhakaran Four new cyclopentadienylruthenium(II)-acetophenone-4(N)-substituted thiosemi-carbazone complexes, with the general formula [Ru(ƞ5-C5H5)(H-Aptsc)PPh3].Cl (1), [Ru(ƞ5-C5H5)(H-Apmtsc)PPh3].Cl (2), [Ru(ƞ5-C5H5)(H-Ap-etsc)PPh3].Cl (3) and [Ru(ƞ5-C5H5)(H-Ap-ptsc)PPh3].Cl (4) were synthesised and characterised (1H NMR, 13C NMR, IR and electronic spectroscopy). The molecular structure of representative complexes 2 and 3 was confirmed by single crystal X-Ray diffraction technique. The binding ability of complexes (1–4) to calf-thymus DNA (CT DNA) and Bovine Serum Albumin (BSA) has been explored by absorption and emission titration methods. Based on the observations, an electrostatic and an intercalative binding mode have been proposed for the complexes with CT-DNA. The BSA protein binding studies have been monitored by quenching of tryptophan and tyrosine residues in the presence of complexes and static type of quenching mechanism has been proposed. In vitro free radical scavenging activity was performed by DPPH radical. The complexes (1–4) exhibited highest scavenging activity than conventional standard vitamin C (IC50 = 5.65 ± 0.12). Further, antibacterial activity of the complexes has been screened against four pathogenic bacteria such as Salmonella paratyphi, Staphylococcus aureus, ...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research

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In this study, the obtained IC50 concentration of 51.25 μg/mL exhibits significant anticancer activity against A549 cells than other tested concentrations because of the release of zinc ions, which induce the cell apoptosis. Furthermore, studies on cell cycle validate that ZnO NPs arrest the cell cycle at the sub-G1 phase of A549 cells. These results suggest the utility of phytogenic ZnO NPs for various biomedical applications.Graphical abstract
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Nehal Salahuddin, Mohamed Abdelwahab, Mohamed Gaber, Sahar ElneanaeyAbstractBiodegradable, biocompatible and non-toxic polymer-based nanoparticles are the novel nanotherapeutic tool which is used for adsorption and encapsulation drugs. Extended release formulation of Norfloxacin antibiotic, chemotherapeutic agent model, drug in the form of encapsulated and loaded poly (lactic acid) nanocomposites-based Titanium dioxide (PLA/TiO2) was developed. Nanocomposites were prepared using different contents (1, 3, 5 wt %) and morphologie...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 14 November 2019Source: Carbohydrate PolymersAuthor(s): Ruzanna Ahmad Shapi’i, Siti Hajar Othman, Norhazirah Nordin, Roseliza Kadir Basha, Mohd Nazli NaimAbstractChitosan nanoparticles (CNP) were synthesized via ionic gelation and used for the preparation of starch-based nanocomposite films containing different concentration of CNP (0, 5, 10, 15, 20% w/w). Antimicrobial properties of starch/CNP films was evaluated via in vitro (disc diffusion analysis) and in vivo (microbial count in wrapped cherry tomatoes) study. It was found that inhibitory zone of the 15 and 20% of starch/CNP fi...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
ConclusionEthyl acetate &Water extracts have represented potent activity against Salmonella typhi, Escherichia coli, &Staphylococcus aureus bacteria as well, provided cytotoxicity against tested cancer cell lines. These results can be explored to identify individual phyto-molecules from the extracts for anticancer &antimicrobial potentials to identify new phytomedicines.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: 2019Source: Materials Today: Proceedings, Volume 19, Part 1Author(s): Α. Ntolia, N. Matisioudis, E. Triantafillou, G. Evangelopoulou, V. Karachristou, E. Rizos, T. Karamanidou, A. Tsouknidas, D. Papadopoulos, D. Tsipas, N. Michailidis, A. AggeliAbstractSilver nanoparticles (AgNPs) constitute a promising approach for the development of new antimicrobial systems. The major global concern about the emergence of bacterial strains resistant to widely used therapeutic agents for human infections has increased research for the discovery of new antimicrobial compounds as therapeutic alternatives. The aim of...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 31 October 2019Source: Food ControlAuthor(s): Brisha Arulrajah, Belal J. Muhialdin, Mohammad Zarei, Hanan Hasan, Nazamid SaariAbstractKenaf seeds are a promising source of natural preservatives for food applications due to their potential as a substrate to generate peptides with high antibacterial activity. We sought to generate bioactive peptides with antibacterial activity from Kenaf seed proteins via lacto-fermentation. The ground seeds were defatted and protein extracted using acid precipitation. Kenaf seed protein was fermented with Lactobacillus casei for 72 h at 37 °C, and the ...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 31 October 2019Source: Food BioscienceAuthor(s): Esmeray Kuley, Mebrure Nüket Yavuzer, Emre Yavuzer, Mustafa Durmuş, Hatice Yazgan, Yekta Gezginç, Fatih ÖzogulAbstractThe impact of safflower (Carthamus tinctorius) and bitter melon (Momordica charantia L.) extracts on growth of fish spoilage bacteria (Acinetobacter lwoffii, Pseudomonas oryzihabitans, Enterobacter cloacae, Shigella spp., Morganella psychrotolerans, Photobacterium phosphoreum) and food-borne pathogens (Staphylococcus aureus, Klebsiella pneumoniae, Enterococcus faecalis, Salmonella Paratyphi A) and their bio...
Source: Food Bioscience - Category: Food Science Source Type: research
In conclusion, SCLP was a potential natural antimicrobial substance with strong antimicrobial activity, which may reduce the use of antibiotics or combat drug-resistant bacteria through synergistic combination with antibiotics. PMID: 31637496 [PubMed - as supplied by publisher]
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Abstract Community-acquired bloodstream infections (CA-BSI) are major causes of severe febrile illness and death worldwide. In light of new data and the growing problem of antimicrobial resistance (AMR) among pathogens causing BSI, we undertook a systematic review of hospital-based studies of CA-BSI among patients hospitalized with fever. Without restriction to language or country, we searched PubMed, Web of Science, and Scopus for prospective hospital-based studies of community-acquired, culture-confirmed BSI among febrile inpatients. We determined by study the prevalence of BSI among participants, pathogens resp...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Publication date: Available online 19 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Mahmoud Amouzadeh Tabrizi, Josep Ferré-Borrull, Lluis F. MarsalAbstractFoodborne Salmonella disease is a major public health concern. Therefore, it is crucial to design a reliable biosensor to the diagnosis of this disease. Herein, we fabricated an interferometric reflectance spectroscopy (IRS) based DNA sensor for the determination of Salmonella-specific DNA fragment concentration. For this purpose, the nanoporous anodic alumina (NAA) was first fabricated. The pore walls of NAA were then functionalized with 3-amino...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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