ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BKCa channels, and nitric oxide dependent mechanisms.

CONCLUSIONS: CB1 and CB2 receptor activation in superior mesenteric artery causes vasorelaxation by mechanisms involving BKCa channels and NO release.
PMID: 29128791 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - July 1, 2017 Category: Drugs & Pharmacology Authors: López-Dyck E, Andrade-Urzúa F, Elizalde A, Ferrer-Villada T, Dagnino-Acosta A, Huerta M, Osuna-Calleros Z, Rangel-Sandoval C, Sánchez-Pastor E Tags: Pharmacol Rep Source Type: research