Association between miR-146a rs2910164 polymorphism and specific cancer susceptibility: an updated meta-analysis

This article will discuss the association between miR-146 rs2910164 polymorphism and cancer susceptibility in 38 independent case-control studies from 34905 individuals. The 38 case-control studies which were searched from PubMed were used for conducting a meta-analysis. There were 14670 cases and 20235 controls. ORs and 95% CIs were used for reflecting the strength of association between miR-146a rs2910164 polymorphism and cancer susceptibility. Subgroup analysis based on the cancer type, ethnicity and study designs. All analysis were performed by using the Stata 11.0 software. MiR-146a rs2910164 polymorphism and overall cancer susceptibility were significantly uncorrelated in all genetic models. In the subgroup analysis for cancer types, miR-146a rs2910164 polymorphism was associated with the susceptibility of lung cancer (CC vs. GG: OR 1.275, 95% CI 1.117 –1.455 (P = 0.000); CC + CG vs. GG: OR 1.166, 95% CI 1.052–1.293 (P = 0.003); CC vs. CG + GG: OR 1.239, 95% CI 1.116–1.375 (P = 0.000); C vs. G OR 1.151, 95% CI 1.080–1.227 (P = 0.000)) and nasopharyngeal carcinoma (CC vs. GG: OR 1.713, 95% CI 1.183–2.479 (P = 0.004); CC vs. CG + GG: OR 1.672, 95% CI 1.330–2.103 (P = 0.000); C vs. G: OR 1.400, 95% CI 1.181–1.659 (P = 0.000)), but it was not associated with hepatocellular carcinoma and gastric cancer. However, in the other subgroup analysis by ethnicity and study designs, no significant associations were found. MiR-146a...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research