Genetic polymorphisms in angiogenesis-related genes are associated with worse progression-free survival of patients with advanced gastrointestinal stromal tumours treated with imatinib

This study explores the relationship of single nucleotide polymorphisms (SNPs) in genes related to imatinib pharmacokinetics and pharmacodynamics and PFS in imatinib-treated patients with advanced GIST.

Source: European Journal of Cancer - October 18, 2017 Category: Cancer & Oncology Authors: Michiel C. Verboom, Jacqueline S.L. Kloth, Jesse J. Swen, Tahar van der Straaten, Judith V.M.G. Bov ée, Stefan Sleijfer, Anna K.L. Reyners, Ron H.J. Mathijssen, Henk-Jan Guchelaar, Neeltje Steeghs, Hans Gelderblom Tags: Original Research Source Type: research