Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs.

Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs. Hear Res. 2017 Oct 31;: Authors: Berger JI, Coomber B, Hill S, Alexander SPH, Owen W, Palmer AR, Wallace MN Abstract Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-implanted awake guinea pigs, before and after salicylate + ACEA. Salicylate-induced reductions in click-evoked ABR amplitudes were smaller in the presence of ACEA, suggesting that the ototoxic effects of salicylate were less severe. ACEA also abolished salicylate-induced changes in cortical alpha band (6-10 Hz) oscillatory activity. However, salicylate-induced increases in cortical evoked activity (suggestive of the presence of hyperacusis) were still present with salicylate + ACEA. ACEA administered alone did not induce significant changes in either ABR amplitudes or oscillatory activity, but did increase ...
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research

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Conditions:   Tinnitus, Subjective;   Hearing Impairment Interventions:   Device: Amplification with hearing aid;   Device: Customized music Sponsors:   Education University of Hong Kong;   Chinese University of Hong Kong Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study used an operant conditioning animal model to examine the interaction between tinnitus and auditory vigilant attention as well as auditory selective attention. Tinnitus was induced in 90-day-old rats by a unilateral exposure to band-limited noise (120 dB, SPL). Tinnitus testing began 90 days following exposure; afterward animals were divided into 3 groups: Unexposed controls without tinnitus, Exposed without tinnitus, and Exposed with tinnitus. Tinnitus was evident in the vicinity of 20 kHz. Vigilant attention was quantified by the behavioral (operant) response to unpredictable sound transitions signaling changes...
Source: Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: Dural arteriovenous fistula is an uncommon intracranial vascular malformation rarely seen by otolaryngologists, with pulsatile tinnitus being the usual presentation. To our knowledge, this is the first reported case of dural arteriovenous fistula presenting with conductive hearing loss and otalgia. PMID: 30322412 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
Conditions:   Tinnitus;   Noise Induced Tinnitus;   Tinnitus, Subjective;   Tinnitus, Objective;   Tinnitus Aggravated;   Tinnitus, Pulsatile;   Tinnitus, Spontaneous Oto-Acoustic Emission;   Tinnitus, Clicking;   Tinnitus, Tensor Tympani Induced Intervention:   Behavioral: Meditation Sponsors:   State University of New York at Buffalo;   University at Buffalo Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Objective and subjective tinnitus can often be differentiated based on comprehensive history, physical examination, and audiogram. Examples of objective tinnitus include vascular abnormalities, palatal myoclonus, patulous eustachian tube, and stapedial/tensor tympani muscle spasm. Subjective tinnitus is usually associated with hearing loss. Rarely, tinnitus is the result of an underlying condition. In these cases, imaging and additional testing may be indicated. Classification of the type, quality, and intensity of tinnitus is helpful in the work-up and treatment of tinnitus. Treatment modalities include cognitive behavior...
Source: Medical Clinics of North America - Category: Primary Care Authors: Source Type: research
ConclusionWe believe the etiology of meningioma in our patients started at childhood and progress to this giant status. We therefore suggest that neurosurgeon's screen children early to detect meningiomas before they advance into giant stages. Two years follow-up after surgery showed no tumor recurrence.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
New medical breakthroughs are helping people suffering from hearing and vision problems. ... Tinnitus could be helped with a sound-therapy system.
Source: AARP.org News - Category: American Health Source Type: news
This study is a randomised controlled trial with a delayed treatment design. Patients with a TMD (TMD pain screener ≥ 3 points) or oral parafunctions (such as clenching and bruxism), who are suffering from moderate to severe subjective tinnitus (Tinnitus Functional Index (TFI) between 25 and 90 points), will be recruited from the tertiary tinnitus clinic of the University Hospital of Antwerp, Edegem, Belgium.Patients will be excluded in case of clear otological or neurological causes of the tinnitus, progressive middle ear pathology, intracranial pathology, traumatic cervical spine or temporomandibular injury in ...
Source: Trials - Category: Research Source Type: clinical trials
Conclusion Based on the results of the current study, we can conclude that the participants improved both the auditory perception and the tinnitus handicap. [...] Thieme Revinter Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: International Archives of Otorhinolaryngology - Category: ENT & OMF Authors: Tags: Original Research Source Type: research
Internet-based cognitive behavioral therapy (iCBT) is at least as effective as standard face-to-face clinical care for reducing distress due to tinnitus, new research shows.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Internal Medicine News Source Type: news
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