PRO 140 Monoclonal Antibody to CCR5 Prevents Acute Xenogeneic Graft-Versus-Host Disease in NOD-Scid IL-2Rynull Mice

• PRO 140 is a humanized monoclonal antibody targeting CCR5• Xeno-GvHD is produced when human BM is transplanted into immunocompromised mice• PRO 140 is effective at blocking xeno-GvHD• PRO 140 did not significantly alter bone marrow stem cell engraftment

Source: Biology of Blood and Marrow Transplantation - November 8, 2017 Category: Hematology Authors: Denis R. Burger, Yvonne Parker, Kathryn Guinta, Daniel Lindner Source Type: research