Number of pulses or number of sessions? An open-label study of trajectories of improvement for once-vs. twice-daily dorsomedial prefrontal rTMS in major depression

Repetitive transcranial magnetic stimulation (rTMS) shows efficacy in the treatment of major depressive episodes (MDEs), but can require ≥4–6 weeks for maximal effect. Recent studies suggest that multiple daily sessions of rTMS can accelerate response without reducing therapeutic efficacy. However, it is unresolved whether therapeutic effects track cumulative number of pulses, or cumulative number of sessions.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 7, 2017 Category: Neurology Authors: Laura Schulze, Kfir Feffer, Christopher Lozano, Peter Giacobbe, Zafiris J. Daskalakis, Daniel M. Blumberger, Jonathan Downar Source Type: research