The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis

CONCLUSIONS: Evaluations of ototoxicity symptoms were not usually reported in the routine care of patients with MDR-TB. Complaints of tinnitus were associated with amikacin and streptomycin use. These results require confirmation in future studies.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

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Publication date: Available online 13 August 2018Source: Food ControlAuthor(s): Xixi Zhao, Yan Zhang, Junling Shi, Yanlin Liu, Yao Lu, Ziyang LianAbstractMulti-drug resistance of foodborne pathogens has been greatly highlighted in food safety and caused a significant challenge for the development of new antibiotics and safe preservatives. The ethanol extract of Phomopsis sp. XP-8 broth showed significant inhibitory effects on multi-drug resistance of foodborne pathogens. After purification with thin-layer chromatography and liquid chromatographic analysis, the antibacterial compound was identified as methyl quercetin accor...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 13 August 2018Source: Redox BiologyAuthor(s): Manbeena Chawla, Saurabh Mishra, Kushi Anand, Pankti Parikh, Mansi Mehta, Manika Vij, Taru Verm, Parul Singh, Kishor Jakkala, H N Verma, Parthasarathi AjitKumar, Munia Ganguli, Aswin Sai Narain Seshasayee, Amit SinghAbstractOxidative stress response in bacteria is mediated through coordination between the regulators of oxidant-remediation systems (e.g. OxyR, SoxR) and nucleoid condensation (e.g. Dps, Fis). However, these genetic factors are either absent or rendered non-functional in the human pathogen Mycobacterium tuberculosis (Mtb). Therefo...
Source: Redox Biology - Category: Biology Source Type: research
This study aims to describe the therapeutic itinerary of homeless persons with tuberculosis, from the initial perception of the symptoms to the moment of hospitalization. Methods: The study used a qualitative approach, containing information and perceptions collected through semi-structured interviews, medical records and the tuberculosis information system. Interviews were interpreted using the discourse content analysis, proposed by Bardin. The theoretical approach adopted to understand their therapeutic itinerary was the health care system model proposed by Arthur Kleinman, in which the popular, professional and folk su...
Source: Physis: Revista de Saude Coletiva - Category: International Medicine & Public Health Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.8b00457
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
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Source: Expert Opinion on Therapeutic Patents - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractA questionnaire-based cross-sectional study was conducted to gather information on current microbiological practices for active surveillance of carriage of multidrug-resistant (MDR) bacteria in hospitals from 14 health departments of the Autonomous Community of Valencia (ACV), Spain, which together provided medical attention to 3,271,077 inhabitants in 2017, approximately 70% of the population of the ACV. The survey consisted of 35 questions on MDR bacteria screening policies, surveillance approach chosen (universal vs. targeted), and microbiological methods and processes in use for routine detection and reporting ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Fine-mapping analysis of a chromosome 2 region linked to resistance to Mycobacterium tuberculosis infection in Uganda reveals potential regulatory variants, Published online: 13 August 2018; doi:10.1038/s41435-018-0040-1Fine-mapping analysis of a chromosome 2 region linked to resistance to Mycobacterium tuberculosis infection in Uganda reveals potential regulatory variants
Source: Genes and Immunity - Category: Genetics & Stem Cells Authors: Source Type: research
[Leadership] The officer in charge of Tuberculosis and Leprosy Control Unit in Gombe State, Dr Mustapha Musa, has said that the state stand the risk of an increase in the number of undetected leprosy cases.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
CONCLUSION: The findings of this investigation demonstrated that the reported prodrugs can add safety and efficacy to future clinical protocols of tuberculosis treatment. PMID: 30079136 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
We present a case report on Cycloserine induced Suicidal tendencies and Kanamycin induced decrease in hearing sensation in Indian MDR-TB patient. CASE REPORT: A 55-year-old male patient who was diagnosed with MDR-TB was prescribed with category IV anti-tubercular therapy. Within one month of initiation of therapy, he developed repeated suicidal thoughts, joint pain, restlessness, depression, constipation, insomnia, tinnitus and a decrease in hearing sensation. RESULTS: Cycloserine and kanamycin were closely associated with suicidal tendency and tinnitus followed by decrease in hearing sensations respectively. On ...
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research
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