The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis

CONCLUSIONS: Evaluations of ototoxicity symptoms were not usually reported in the routine care of patients with MDR-TB. Complaints of tinnitus were associated with amikacin and streptomycin use. These results require confirmation in future studies.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

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Background: As one of the most frequent and serious adverse reactions during tuberculosis (TB) treatment, antituberculosis drug-induced liver injury (ATLI) in children has been studied insufficiently compared with adults. We aimed to determine the incidence and risk factors of ATLI in children during the first 2 months of TB therapy. Methods: A total of 41 children with TB and treated with first-line anti-TB drugs were prospectively followed-up for the development of ATLI. Liver function tests were performed at baseline and after 2 weeks of therapy. Subsequent tests were conducted at 4, 6 and 8 weeks if the initial 2-...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
In the Canadian province with the highest rates of active tuberculosis, researchers say more data and better tracking of the potentially deadly disease could help stem the spread.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news
In a province with the highest rates of active tuberculosis in Canada, researchers say more data and better tracking of the potentially deadly disease could help stem the spread.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02832J, CommunicationJia-Hua Huang, Jian-Ming Lv, Qiao-Zhen Wang, Jian Zou, Yongjun Lu, Qing-Lin Wang, Dongni Chen, Xin-Sheng Yao, Hao Gao, Dan Hu A putative three-gene cluster for asperterpenoid A was identified. Step-wise reconsitution of this gene cluster in Aspergillus oryzae reveals that astC encodes a sesterterpene cyclase to synthesize preasperterpenoid A, which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Story updated at 3:00 p.m. (Pacific Time) RIO DE JANEIRO (AP) — A man opened fire in a cathedral in southern Brazil after Mass on Tuesday, killing four people and wounding four more before taking a bullet in the ribs in a firefight with police and then shooting himself in the head, authorities said. The shooting happened right after the midday service had ended at the Metropolitan Cathedral in Campinas, a city about 60 miles (100 kilometers) north of Sao Paulo. "It's so sad," said Wilson Cassante, a press officer with the archdiocese. "It's hard to imagine the pain this has caused." Hours after pa...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Authors: Tags: News Terrorism & Active Shooter Source Type: news
Publication date: Available online 11 December 2018Source: Microbial PathogenesisAuthor(s): Xiaoling Wu, Jiamei Zhang, Chenjie Ma, Wu Li, Jin Zeng, Yujiong Wang, Guangcun DengAbstractMycobacterium tuberculosis (Mtb)-induced autophagy of alveolar macrophages has been confirmed to play a central role in the pathogenesis of tuberculosis. Growing evidence indicates that excessive or uncontrolled autophagic activity, which results in type II programmed cell death, can be regulated by many factors, including Wnt/β-catenin signalling. Wnt/β-catenin signalling has been demonstrated to be involved in multiple diseases thr...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Conclusions: In HIV infection, TB may contribute to cognitive impairment, even after controlling for lower CD4 counts and viral load. Thus, systemic inflammation from HIV and TB and more advanced immune deficiency at diagnosis of HIV may contribute to impaired cognition in HIV+/TB+ patients.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Clinical Science Source Type: research
ConclusionsThis study suggests a trend towards regionalization and volume-outcome relationships for PD due to PC, as large metropolitan integrated municipalities registered most of the PDs and more stable mortality rates. The substantial differences between PD and PC increasing rates reveals a limiting step on the health system resoluteness. Reduction in the number of hospital beds and late access to hospitalization, despite improvement in diagnostic methods, could at least in part explain these findings.
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
Background: Multidrug Resistance TB (MDR-TB) is a growing threat to TB control programme. Its treatment in children is challenging, yet most developing countries do not specifically address pediatric MDR-TB.Methods: A prospective study conducted in Khyber Pakhtunkhwa (KPK) province of country Pakistan. Analysis of data for 160 children
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
We present a case report on Cycloserine induced Suicidal tendencies and Kanamycin induced decrease in hearing sensation in Indian MDR-TB patient. CASE REPORT: A 55-year-old male patient who was diagnosed with MDR-TB was prescribed with category IV anti-tubercular therapy. Within one month of initiation of therapy, he developed repeated suicidal thoughts, joint pain, restlessness, depression, constipation, insomnia, tinnitus and a decrease in hearing sensation. RESULTS: Cycloserine and kanamycin were closely associated with suicidal tendency and tinnitus followed by decrease in hearing sensations respectively. On ...
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research
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