Cationic nanoemulsions as nucleic acids delivery systems

Publication date: 20 December 2017 Source:International Journal of Pharmaceutics, Volume 534, Issues 1–2 Author(s): Helder Ferreira Teixeira, Fernanda Bruxel, Michelle Fraga, Roselena Silvestri Schuh, Giovanni Konat Zorzi, Ursula Matte, Elias Fattal Since the first clinical studies, knowledge in the field of gene therapy has advanced significantly, and these advances led to the development and subsequent approval of the first gene medicines. Although viral vectors-based products offer efficient gene expression, problems related to their safety and immune response have limited their clinical use. Thus, design and optimization of nonviral vectors is presented as a promising strategy in this scenario. Nonviral systems are nanotechnology-based products composed of polymers or lipids, which are usually biodegradable and biocompatible. Cationic liposomes are the most studied nonviral carriers and knowledge about these systems has greatly evolved, especially in understanding the role of phospholipids and cationic lipids. However, the search for efficient delivery systems aiming at gene therapy remains a challenge. In this context, cationic nanoemulsions have proved to be an interesting approach, as their ability to protect and efficiently deliver nucleic acids for diverse therapeutic applications has been demonstrated. This review focused on cationic nanoemulsions designed for gene therapy, providing an overview on their composition, physicochemical properties, and their effi...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Publication date: January–February 2019Source: Reports of Practical Oncology &Radiotherapy, Volume 24, Issue 1Author(s): Rut Cañas, Isabel Linares, Ferran Guedea, Miguel Ángel BerenguerAbstractRadiological Oncology, like the rest of medical specialties, is beginning to provide can personalized therapies. The ongoing scientific advances enable a great degree of precision in diagnoses and therapies. To fight cancer, from a radiotherapy unit, requires up-to-date equipment, professionals with different specialties working in synchrony (doctors, physicists, biologists, etc.) and a lot of research. Some o...
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Bacteria-mediated delivery of RNAi effector molecules against viral HPV16-E7 eradicates oral squamous carcinoma cells (OSCC) via apoptosis, Published online: 15 November 2018; doi:10.1038/s41417-018-0054-xBacteria-mediated delivery of RNAi effector molecules against viral HPV16-E7 eradicates oral squamous carcinoma cells (OSCC) via apoptosis
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
Today, I'll point out an analysis from the SENS Research Foundation that covers the approach to selective destruction of senescent cells taken by one of the newly formed biotech startups in the space, Senolytic Therapeutics. This field is hot because it is now well proven that senescent cells are the enemy. They are one of the root causes of aging, accumulating with age to degrade tissue function via the secretion of inflammatory signal molecules. Senescent cells actively maintain an aged, inflamed state of metabolism, resulting in the development of age-related disease and increased mortality. Senescent cells do se...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
(Mary Ann Liebert, Inc./Genetic Engineering News) Mice with heart failure that were treated with AAV8-based gene therapy to deliver the protein urocortin 3 (UCn3) had increased blood levels of UCn3 over a 5-week period and improved heart function.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
AbstractPrimary hyperoxalurias (PHs) are rare inherited disorders of liver glyoxylate metabolism, characterized by the abnormal production of endogenous oxalate, a metabolic end-product that is eliminated by urine. The main symptoms are related to the precipitation of calcium oxalate crystals in the urinary tract with progressive renal damage and, in the most severe form named Primary Hyperoxaluria Type I (PH1), to systemic oxalosis. The therapies currently available for PH are either poorly effective, because they address the symptoms and not the causes of the disease, or highly invasive. In the last years, advances in ou...
Source: Urolithiasis - Category: Urology & Nephrology Source Type: research
All patients diagnosed with malignant mesothelioma should undergo genetic testing to better identify the most appropriate treatment plan, according to Dr. Michele Carbone, the director of thoracic oncology at the University of Hawaii Cancer Center. Genetic testing also could lead to a more accurate prognosis and help family members determine if they are more susceptible to the cancer. Carbone estimates only one-third of all mesothelioma patients today have undergone the testing. “Some of these patients could definitely benefit from genetic testing,” Carbone told The Mesothelioma Center at Asbestos.com. Carbon...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
We are in a wondrous age of medicine where CURES for certain types of cancer, rare diseases, blindness and other scourges are imminent. We now need to figure out how to pay for them.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: NASDAQ:AVXS NYSE:NVS Source Type: news
“I’m a medical student. Which specialty should I choose and what skills will a future doctor need?” “I’m in radiology. Looking at the recent advancements in medical technology, was it a wise choice or should I train myself in something different, too?” These are the questions I most frequently receive after my keynote speeches. While all should be aware of their own physical and intellectual capabilities, here are a few pieces of advice which skills to concentrate on based on the current and future trends in healthcare. The most significant trends in healthcare Artificial intelligence, w...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Medical Education Medical Professionals capabilities crowdsourcing digital digital health digital literacy gamification Healthcare Innovation medical specialties medical specialty patient design skills tech Source Type: blogs
(Mary Ann Liebert, Inc./Genetic Engineering News) A combinatorial gene therapy approach -- one designed to inhibit inflammation and one targeting protection against cartilage degeneration -- was shown to preserve articular carti-lage better than each approach alone in animal models of both moderate and severe post-traumatic osteoarthritis.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
uang Vannajan Sanghiran Lee Khuanchai Suparatpinyo Chatchai Tayapiwatana Certain proteins have demonstrated proficient human immunodeficiency virus (HIV-1) life cycle disturbance. Recently, the ankyrin repeat protein targeting the HIV-1 capsid, AnkGAG1D4, showed a negative effect on the viral assembly of the HIV-1NL4-3 laboratory strain. To extend its potential for future clinical application, the activity of AnkGAG1D4 in the inhibition of other HIV-1 circulating strains was evaluated. Chimeric NL4-3 viruses carrying patient-derived Gag/PR-coding regions were generated from 131 antiretroviral drug-naïve ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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