BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity
This study suggests that alternate modes of target inhibition, such as ERK inhibition, will be required to effectively treat tumors harboring these MEK1/2-resistant alleles. Mol Cancer Res; 15(10); 1431–44. ©2017 AACR.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Emery, C. M., Monaco, K.-A., Wang, P., Balak, M., Freeman, A., Meltzer, J., Delach, S. M., Rakiec, D., Ruddy, D. A., Korn, J. M., Haling, J., Acker, M. G., Caponigro, G. Tags: Signal Transduction Source Type: research
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