Mesenchymal stromal cells improve human islet function through released products and extracellular matrix

Conclusions: Our results suggest that hASCs have the potential to improve the quality of human islets isolated for transplantation therapy of Type 1 diabetes. Furthermore, it may be possible to achieve improvements in human islet quality in a cell-free culture system by using the MSC-derived products ANXA1 and ECM.

Source: Clinical Science - November 3, 2017 Category: Biomedical Science Authors: Arzouni, A. A., Vargas-Seymour, A., Rackham, C. L., Dhadda, P., Huang, G.-C., Choudhary, P., Nardi, N., King, A. J. F., Jones, P. M. Tags: PublishAheadOfPrint Source Type: research