Bone Marrow Cell Transplantation Time-Dependently Abolishes Efficacy of Granulocyte Colony-Stimulating Factor After Stroke in Hypertensive Rats [Basic Sciences]

Conclusions— G-CSF improved functional recovery in spontaneously hypertensive rats, but this effect was abolished by cotransplantation of BM MNC after 48 hours. In the spleen, transplanted cells may hinder the clearance of granulocytes that were massively increased by G-CSF. Increased circulation and infiltration of granulocytes into the ischemic brain may be detrimental for stroke outcome.

http://stroke.ahajournals.org/cgi/content/short/45/8/2431?rss=1

Source: Stroke - July 28, 2014 Category: Neurology Authors: Posel, C., Scheibe, J., Kranz, A., Bothe, V., Quente, E., Frohlich, W., Lange, F., Schabitz, W.-R., Minnerup, J., Boltze, J., Wagner, D.-C. Tags: Animal models of human disease, Acute Cerebral Infarction, Pathology of Stroke Basic Sciences Source Type: research