Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy

Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascula...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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Conclusions: These results indicate that insulin effectively suppresses left ventricular cardiomyocyte ultrastructural damage, which substantially slows down the progression of diabetic cardiomyopathy for 8 weeks in a rat model of T1DM, possibly due to the glycemic control and inhibition of dyslipidemia, OxS and inflammation.Pharmacology
Source: Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health probl...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Bartolo Ferraro1,2, Maria Donniacuo3, Loredana Sodano3, Franca Ferraraccio4, Rosa Maisto3, Eliana Gulotta5, Gorizio Pieretti6, Michele D’Amico3*, Maria Consiglia Trotta3 and Barbara Rinaldi3 1Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University of Munich, Munich, Germany 2DZHK, Partner Site Munich Heart Alliance, Munich, Germany 3Department of Experimental Medicine, Pharmacology Division, University of Campania “L. Vanvitelli”, Naples, Italy 4Department of Clinical, Public and Preventive Medicine, University of Campania “L. Vanvitelli”, Naples, Italy 5Departm...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: This study observed an inverse correlation between plasma LDL cholesterol and heart function in individuals with T2DM. Patients with higher levels of plasma LDL cholesterol had worse left ventricular function. Therefore, plasma LDL cholesterol may be a modifiable risk factor of heart failure in diabetes, but prospective studies are necessary to confirm this finding. Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disease that affects a considerable number of patients worldwide (1). Among diabetic individuals, cardiovascular disease (CVD) is the leading cause of morbidity and mortality (2). C...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 15 March 2019Source: Journal of Pharmacological SciencesAuthor(s): Sheng-gao Tang, Xiao-yu Liu, Shan-ping Wang, Hong-hui Wang, Aleksandar Jovanović, Wen TanAbstractDiabetic cardiomyopathy (DCM) is characterized by cardiac hypertrophy, fibrosis, oxidative stress and inflammation. Trimetazidine (TMZ), a potent metabolism modulator, has been shown to be cardioprotective in experimental models of ischaemia-reperfusion and type 2 diabetes-induced cardiomyopathy. The present study examined whether TMZ inhibits cardiomyopathy induced by insulin-dependent type 1 diabetes. Wistar rats were random...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Diabetes mellitus is a chronic and complex disease affecting over 30.3 million people in the United States [3]. As a chronic disease, diabetes requires intensive monitoring and management on the part of patients and their healthcare providers. Both type 1 and type 2 diabetes are associated with acute and long-term medical complications and comorbidities including neuropathy, retinopathy, diabetic cardiomyopathy, and overall mortality (e.g., [24,30]. Diabetes is also associated with multiple co-morbid psychological conditions such as depression and anxiety as well as psychological conditions that are specific to the disease...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
In this study; the diabetic group showed statistically highly significant decrease in the average RV-GLS (−14.0 ± 6.9 in group 1 vs. −22.7 ± 2.5 in group 2, P 
Source: Indian Heart Journal - Category: Cardiology Source Type: research
AbstarctDiabetic complications are among the largely exigent health problems currently. Cardiovascular complications, including diabetic cardiomyopathy (DCM), account for more than 80% of diabetic deaths. Investigators are exploring new therapeutic targets to slow or abate diabetes because of the growing occurrence and augmented risk of deaths due to its complications. Research on rodent models of type 1 and type 2 diabetes mellitus, and the use of genetic engineering techniques in mice and rats have significantly sophisticated for our understanding of the molecular mechanisms in human DCM. DCM is featured by pathophysiolo...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
In this study; the diabetic group showed statistically highly significant decrease in the average RV-GLS (-14.0±6.9 in group 1 vs. -22.7±2.5 in group 2, P
Source: Indian Heart J - Category: Cardiology Authors: Tags: Indian Heart J Source Type: research
Conclusion: Type 1 diabetes mellitus influenced linear indexes and symbolic analysis, but not yet in the complexity of heart rate variability. Additionally, heart rate variability indexes correlated with the symbolic dynamics.Resumo Fundamento: O diabetes melito tipo 1 pode promover altera ções autonômicas, que podem ser avaliadas pela variabilidade da frequência cardíaca. Dentre os métodos da variabilidade da frequência cardíaca, têm ganhado destaque a análise simbólica e a entropia de Shannon, baseadas na dinâmica do caos. Objetivo: Comparar &...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
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