This Month in The Journal

As the population ages, an increasing number of people  develop neurodegenerative disease. Frontotemporal lobar degeneration (FTLD) causes early-onset dementia and is fatal in all cases. Information gained from family-based and genome-wide association studies has yielded insights into genetic risk factors, but moving from a risk locus to a disease mech anism is not trivial. In this issue, Gallagher et al. take a closer look at one such FTLD-associated locus, 7p21. Previous studies have zeroed in on one gene in this region, TMEM106B; however, the mechanism by which variation in this gene alters FTLD risk has remained elusive.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Editors' Corner Source Type: research