Ancestral Genome Reconstruction on Whole Genome Level.

Ancestral Genome Reconstruction on Whole Genome Level. Curr Genomics. 2017 Aug;18(4):306-315 Authors: Feng B, Zhou L, Tang J Abstract Comparative genomics, evolutionary biology, and cancer researches require tools to elucidate the evolutionary trajectories and reconstruct the ancestral genomes. Various methods have been developed to infer the genome content and gene ordering of ancestral genomes by using such genomic structural variants. There are mainly two kinds of computational approaches in the ancestral genome reconstruction study. Distance/event-based approaches employ genome evolutionary models and reconstruct the ancestral genomes that minimize the total distance or events over the edges of the given phylogeny. The homology/adjacency-based approaches search for the conserved gene adjacencies and genome structures, and assemble these regions into ancestral genomes along the internal node of the given phylogeny. We review the principles and algorithms of these approaches that can reconstruct the ancestral genomes on the whole genome level. We talk about their advantages and limitations of these approaches in dealing with various genome datasets, evolutionary events, and reconstruction problems. We also talk about the improvements and developments of these approaches in the subsequent researches. We select four most famous and powerful approaches from both distance/event-based and homology/adjacency-based categories to analyze a...
Source: Current Genomics - Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research