Nigeria:Ikudayisi - Adult Stem Cell Can Tackle Diabetes, Heart Diseases, Infertility

[This Day] David Ikudayisi, a Nigerian-American Specialist in regenerative medicine, is the Medical Director, Glory Wellness and Regenerative Centre. In this interview with Martins Ifijeh, he spoke on Adult Stem Cell Therapy as an emerging approach to tackling myriads of health challenges, including diabetes, heart issues, infertility, baldness, among others
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Source: BMJ Comments - Category: General Medicine Source Type: forums
In this study, we screened 110 Taiwanese children (61 males and 49 females) with T1D onset before the age of 5 years for mutations of INS and KCNJ11. We identified one missense heterozygous mutation in KCNJ11 (c.989A>G, p.Y330C) and no INS mutations among 28 probands. This is the first study to screen patients with autoantibody-negative T1D diagnosed before the age of 5 years for INS and KCNJ11 mutations in Taiwan. Although KCNJ11 mutations are always reported in patients with permanent neonatal diabetes, this gene mutation can be detected after 6 months of age. Further studies in other patients with type 1B diabetes an...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Publication date: August 2018Source: Journal of the Formosan Medical Association, Volume 117, Issue 8Author(s): Yi-Chih Lin, Yu-Hsing Chang, Shao-Yu Yang, Kwan-Dun Wu, Tzong-Shinn ChuDiabetic kidney disease (DKD) is a major cause of morbidity and mortality in patients with diabetes mellitus and the leading cause of end-stage renal disease in the world. The most characteristic marker of DKD is albuminuria, which is associated with renal disease progression and cardiovascular events. Renal hemodynamics changes, oxidative stress, inflammation, hypoxia and overactive renin-angiotensin-aldosterone system (RAAS) are involved in ...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Publication date: Available online 20 July 2018Source: Alzheimer's &DementiaAuthor(s): Juan Antonio García-León, Alfredo Cabrera-Socorro, Kristel Eggermont, Ann Swijsen, Joke Terryn, Raheem Fazal, FatemehArefeh Nami, Laura Ordovás, Ana Quiles, Frederic Lluis, Lutgarde Serneels, Keimpe Wierda, Annerieke Sierksma, Mohamed Kreir, Francisco Pestana, Philip Van Damme, Bart De Strooper, Lieven Thorrez, Andreas Ebneth, Catherine M. VerfaillieAbstractTauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease amo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
ConclusionsThe experimental results from the pharmacological research enable the validation of their traditional uses in several of the groups of diseases in the countries of origin and reveal these plants to be a valuable source for therapeutic molecules. However, more toxicity assays and clinical trials would be necessary to establish optimal and safe doses of consumption on the application of these medicinal plants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Setareh Esmailian, Shiva Irani, Hadi Bakhshi, Mojgan ZandiAbstractBead-on-string mats based on poly(lactide-co-glycolide) (PLGA) releasing β-carotene (βC) as a natural osteogen were fabricated and used for bone tissue engineering. Mesenchymal stem cells (MSCs) seeded on the scaffolds successfully differentiated to osteoblasts without using any a differential medium. The mats showed a small burst of β-carotene (24–27%) during the first day and a sustained slow release up to 21 days. The MTT and SEM resul...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
This study provided a novel mechanism of forming interpenetrating network (IPN) of gelatin methacryloyl (GelMA) and CS hydrogels by covalent bonds and hydrophobic interactions through photocrosslinking and basification, respectively. By characterization of the compressive and tensile moduli, ultimate tensile stress and strain, it was found that semi-IPN and IPN structure can greatly enhance the mechanical properties of GelMA-CS hydrogels compared to the single network CS or GelMA. Moreover, the increase of either GelMA or CS concentration can strengthen the hydrogel network. Then, the swelling, enzymatic degradation, and m...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Natalia V. Bulina, Marina V. Chaikina, Igor Yu Prosanov, Ekaterina G. Komarova, Mariya B. Sedelnikova, Yurii P. Sharkeev, Vladimir V. SheikinAbstractLanthanum–silicate substituted apatite with equal concentrations of the substituents in the range of 0.2–6.0 mol were produced by a fast method – mechanochemical synthesis. This method makes it possible to synthesize a nanosized single–phase product by activating reaction mixtures containing CaHPO4, CaO, La(OH)3 and SiO2·H2O for 25–30 min ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Richa Panwar, Navdeep Raghuwanshi, Amit Kumar Srivastava, Asvene K. Sharma, Vikas PruthiAbstractDiabetes mellitus (DM) is one of the most common lifestyle diseases, caused due to endocrine disorder. DM is commonly associated with hyperglycemia, a condition which is generally followed by an overproduction of free radicals leading to tissue oxidative stress. Currently, the focus of medical fraternity lies in developing therapeutic drugs based on natural origin in order to reduce the hyperglycemia associated toxicity. Ferulic ac...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, changes in the molecular structure of UV/ozone-modified polystyrene were characterized to optimize the surface chemistry for iPSC. Mouse iPSCs (miPSCs) were cultured on the UV/ozone-modified polystyrene substrates without feeder layers. As a result, large polymeric chains of polystyrene were dissociated into small polymeric chains and oxidized to form ester and carboxylic acid functional groups by the UV/ozone treatment. Moreover, it was suggested that optimal valance of these modified molecules enabled the feeder- and matrix coating-free culture of miPSC with maintaining pluripotency.
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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