Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Altered regulation of extracellular matrix (ECM) composition by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) may contribute to arterial stiffening. We investigated associ...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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Conclusions: Using CSII in T1D leads to a significant increase of SMM in both sexes to a decrease of VFA in men and to a non-significant decrease of VFA in women. Changes in adipose tissue and SMM were also related to increased physical activity and to decreased GV.Obes Facts 2018;11:454 –464
Source: Obesity Facts - Category: Eating Disorders & Weight Management Source Type: research
For teens with type 1 diabetes, becoming an adult can mean losing continuous care and the insulin they need to survive. What can clinicians do to safely guide patients across the bridge to adult care?Medscape Diabetes &Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Article Source Type: news
CONCLUSION: Among T1DM patients, 71% had IQVJD scores compatible with better HRQOL.RESUMO A qualidade de vida relacionada à saúde (HRQOL) no diabetes mellitus tipo 1 (T1DM) tem sido amplamente estudada. Os objetivos deste estudo foram avaliar e identificar os fatores que influenciam a HRQOL de crianças e adolescentes com T1DM. MATERIAL E MÉTODOS: No total, 59 pacientes (9-16 anos, T1DM por ≥ 1 ano) responderam a uma vers ão do Instrumento de Qualidade de Vida para Jovens com Diabetes (DQOLY) adaptada aos pacientes brasileiros (IQVJD). Esse instrumento compreende satisfaçã...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
Type 1 diabetes is the only chronic, life threatening disease where the dosing decisions of a potentially lethal hormone are left in the hands of the patient alone. There is technology that can catch errors quickly, but the costs fall on patients and their families.
Source: CBC | Health - Category: Consumer Health News Tags: News/Opinion Source Type: news
Authors: Ţânţu MM, Man GM, Rogozea LM, Domnariu CD, Pleşa FC, Traşcă DM, Cotoi BV, Stoica LE, Nicolae C, Nemeş RM Abstract Our study included a total of 259 patients with diabetes, who were admitted to the Department of Plastic Surgery and Reconstructive Microsurgery of the Emergency County Hospital of Piteşti, Romania, in 2016, with the diagnosis of "diabetic foot". Of the 259 patients, 55 (21.23%) were diagnosed with type 1 diabetes, and the remaining 204 (78.77%) were diagnosed with type 2 diabetes; the ratio of type 1∕type 2 diabetes was 1∕3.7. The injuries presented by the patients w...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
AbstractIntroductionThe aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.MethodsPost hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
CONCLUSIONS Our study reports a significant association of the CEP135 single nucleotide polymorphism rs4865047 genotype with rapidly progressive proliferative diabetic retinopathy and the control group. No significant association was found of the NPY2R single nucleotide polymorphism rs1902491 genotype. PMID: 30531682 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusion: The intrinsic challenges of adolescence and the way pre-adolescents with diabetes handle the disease have an influence on diabetes management and create needs that must be appreciated by health care professionals in order to provide self-care support.RESUMEN Objetivo: Analizar las necesidades de preadolescentes con diabetes tipo 1 para el autocuidado apoyado en el manejo de la enfermedad. M étodo: Investigación cualitativa, llevada a cabo entre octubre y diciembre de 2016 con preadolescentes atendidos en un ambulatorio hospitalario y en Unidades de Salud de la Familia, utilizándose entrevis...
Source: Revista da Escola de Enfermagem da USP - Category: Nursing Source Type: research
DiscussionIf effective, the Baby Steps programme could be translated into a primary care-based intervention that women with GDM are referred to in the postnatal period. This could help them make lifestyle changes that could reduce their future risk of T2D.Trial registrationISRCTN,ISRCTN17299860. Registered on 5 April 2017.
Source: Trials - Category: Research Source Type: clinical trials
AbstractIn a study of 199 couples in which one person had type 1 diabetes, we examined how patient appraisal of the diabetes as shared versus individual was associated with collaborative, supportive and unsupportive behavior and whether patient shared illness appraisal was most beneficial for health when it occurred in the context of supportive behavior. We assessed illness appraisal among patients with type 1 diabetes and their partners and had patients complete relationship and health measures. Results showed partners were more likely than patients to hold shared illness appraisals. Patients ’ shared appraisals wer...
Source: Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
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