Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature.

Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature. Adv Exp Med Biol. 2017;967:179-194 Authors: Pabelick CM, Thompson MA, Britt RD Abstract Although it is necessary and part of standard practice, supplemental oxygen (40-90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung. PMID: 29047087 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research