Computer aided drug design and its application to the development of potential drugs for neurodegenerative disorders.

Computer aided drug design and its application to the development of potential drugs for neurodegenerative disorders. Curr Neuropharmacol. 2017 Oct 16;: Authors: Baig MH, Ahmad K, Rabbani G, Danishuddin, Choi I Abstract Neurodegenerative disorders (NDs) are diverse group of disorders characterized by dysfunctioning neurons in the central nervous system, and the search for potent drugs to treat NDs continues to attract considerable research interest. In this era of advance techniques, Computer-Aided Drug Design (CADD) has emerged as an efficient means of developing candidate drugs for the treatment of many disease types. In this review, we have briefly described about CADD and its use in the development of the therapeutic drug candidates against NDs. Here we have also discussed successful application of CADD in NDs. Moreover the successful applications, limitations and future prospects of this approach have also been discussed. We believe this review will be helpful for better understanding of CADD and towards the discovery of new drugs candidates against various NDs. PMID: 29046156 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research