Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2, allowing target gene activation [Molecular Bases of Disease]

In conclusion, our findings have identified critical molecular mechanisms involving ERK-mediated ERG activation that could be exploited for therapeutic intervention in ERG-positive prostate cancers.

Source: Journal of Biological Chemistry - October 20, 2017 Category: Chemistry Authors: Vivekananda Kedage, Brady G. Strittmatter, Paige B. Dausinas, Peter C. Hollenhorst Tags: Gene Regulation Source Type: research