Muscle specific differences in expression and phosphorylation of the Janus kinase 2/ Signal Transducer and Activator of Transcription 3 following long ‐term mechanical ventilation and immobilization in rats

ConclusionThe JAK2/STAT3 pathway was differentially activated in plantaris, intercostal, and diaphragm muscles in response to the ICU condition. Thus, JAK2/STAT3 inhibitors may provide an attractive pharmacological intervention strategy in immobilized ICU patients, but further experimental studies are required in the study of muscle‐specific effects on muscle mass and function in response to both short‐ and long‐term exposure to the ICU condition prior to the translation into clinical research and practice.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - Category: Physiology Authors: Tags: Regular Paper Source Type: research