Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Recent estimates suggest that>300 million people are afflicted by serious fungal infections worldwide. Currentantifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of newantifungal drugs. The fungal sphingolipid glucosylceramide (GlcCer) is critical in promoting virulence of a variety of human-pathogenic fungi.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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We report on 24 p40phox-deficient patients from 12 additional families in 8 countries. These patients display 8 different in-frame or out-of-frame mutations of NCF4 that are homozygous in 11 of the families and compound heterozygous in another. When overexpressed in NB4 neutrophil-like cells and EBV-transformed B cells in vitro, the mutant alleles were found to be LOF, with the exception of the p.R58C and c.120_134del alleles, which were hypomorphic. Particle-induced NADPH oxidase activity was severely impaired in the patients’ neutrophils, whereas PMA-induced dihydrorhodamine-1,2,3 (DHR) oxidation, which is widely u...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
2018Post date: Wednesday, August 1, 2018 - 15:35Books and theses
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
AbstractPurpose of ReviewThe purpose of this review is to give an overview of recent findings on antifungal resistance inAspergillus fumigatus (the major causative agent of aspergillosis) and siblingAspergillus species, which can be hidden agents of aspergillosis.Recent FindingsAzole resistance by Cyp51A mutation inA.fumigatus is a growing problem worldwide. The resistance can occur in patients or in the environment. The former occurs by drug selection in the host, inducing mutations in Cyp51A. The latter is characterized by a tandem repeat in the promoter region ofcyp51A gene and mutation(s) in Cyp51A. Environmental resis...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Publication date: Available online 10 July 2018Source: Medical Mycology Case ReportsAuthor(s): Peter F. Bennett, Jessica J. Talbot, Patricia Martin, Sarah E Kidd, Mariano Makara, Vanessa R. BarrsAbstractCanine disseminated fungal infection by Aspergillus species carries a guarded to grave prognosis as they often rapidly progress and are refractory to treatment with many euthanased soon after diagnosis. This case report describes a 2.5 year old female spayed German Shepherd Dog diagnosed with disseminated Aspergillus deflectus infection for which definitive treatment was declined by the owners. With only palliative manageme...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Purpose of review An opportunistic mycosis is a fungal agent of low pathogenicity that specifically infects immunocompromised hosts. Advances in transplantation, preterm care, immunosuppressive therapies and intensive care, have lead to the emergence of pediatric patients with serious immunodeficiency who are vulnerable to nonpathogenic fungi. Recent findings The advent of the use of biologic agents in pediatric disease as well as the advances in care of preterm and immunosuppressed patients opens up a new cohort of patients at risk of opportunistic mycotic infections. Recent cases of cutaneous histioplasmosis as the ...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: DERMATOLOGY: Edited by Joyce M.C. Teng Source Type: research
ConclusionOur result demonstrate that the RLB assay potentially is suitable for rapid and simultaneous identification of variety fungal pathogens directly from culture as well as from clinical specimens.
Source: Journal of Medical Mycology - Category: Biology Source Type: research
ConclusionBG assay is better for detection of IFI in patients with immunosuppression. However, a combination of both BG and GM assays would be the best approach as BG assay is highly sensitive, while the GM assay is highly specific for diagnosing IFI.
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
ConclusionsWe conclude that micafungin was clinically effective for the treatment of invasive candida and aspergillus infections and that usage did not increase the risk of liver dysfunction even in patients with abnormal ALT at baseline.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionA high level of suspicion of invasive fungal infection is required at all times in immunosuppressed patients, even those receiving antifungal prophylaxis. Early biopsy is required. Even with early recognition and aggressive treatment of these infections, prognosis is poor.
Source: IDCases - Category: Infectious Diseases Source Type: research
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