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Antifungal activities of R-135853, a sordarin derivative, in experimental candidiasis in mice

The activities ofR-135853, a novel sordarin derivative that possesses a 1,4-oxazepane ring moiety, were evaluated in vitro and in vivo.R-135853 exhibited potent in vitro activities against Candida albicans (fluconazole-susceptible strains), Candida glabrata, Candida tropicalis, and Cryptococcus neoformans, with MICs at which 90% of isolates were inhibited of 0.03, 1, 0.5, and 0.5 microg/ml, respectively.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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In conclusion, a dysbiotic mycobiome dominated by C. albicans was found in association with OSCC, a finding worth further investigation. PMID: 29152157 [PubMed]
Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
Methyl (3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzoyl)glycinate (1), a new sydonic acid derivative with glycinate, together with sydonic acid (2), sydowic acid (3), and 7-deoxy-7,14-didehydrosydonic acid (4), were isolated from a marine-derived Aspergillus sydowii strain CUGB-F126. Their structures were elucidated by spectroscopic analysis, including high-resolution mass spectroscopy, and 1D and 2D NMR techniques. All of these compounds did not show inhibitory activity against Staphylococcus aureus and Candida albicans.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
Publication date: Available online 13 November 2017 Source:Saudi Pharmaceutical Journal Author(s): Nouf M. Al-Enazi, Amani S. Awaad, Saleh I. Alqasoumi, Metab F. Alwethairi The biological activities; antimicrobial, antioxidant and anticancer, of the red algae Galaxaura rugosa and Liagora hawaiiana were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However, the chloroform extract of Galaxaura rugosa showed antibacterial activity against Klebsiella pneumoniae (24 mm, 0.15 mg/ml) higher than gentamycin (23 mm, ...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 10 November 2017 Source:Saudi Pharmaceutical Journal Author(s): Nouf M. Al-Enazi, Amani S. Awaad, Mohamed E. Zain, Saleh I. Alqasoumi The antimicrobial, antioxidant, and anticancer activities of ethanolic extract of Laurencia catarinensis, L. majuscula and Padina pavonica were determined. The highest antibacterial activity; 23.40 ± 0.58 mm (00.98 µg/ml) and 22.60 ± 2.10 mm (03.90 µg/ml) were obtained against Klebsiella pneumonia by Laurencia catarinensis and Padina pavonica, respectively. However, Padina pavonica showed excellent antibacterial ac...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
A novel azo dye ligand, namely 1‐[(5‐mercapto‐1H‐1,2,4‐triazole‐3‐yl)diazenyl]naphthalen‐2‐ol (HL), was synthesized. Mn2+, Co2+, Ni2+, Cu2+ and UO22+ complexes were also prepared by the treatment of HL with Mn(CH3COO)2⋅4H2O, Co(CH3COO)2⋅4H2O, Ni(CH3COO)2⋅4H2O, Cu(CH3COO)2⋅H2O, CuCl2⋅2H2O, Cu(NO3)2⋅6H2O and UO2(NO3)2⋅6H2O. The structures of these metal chelates were confirmed using elemental, spectral, magnetic moment, molar conductance and thermal analyses. The analytical data confirmed the formation of the chelates in 1:1 (metal‐to‐ligand) ratio having the formula [...
Source: Applied Organometallic Chemistry - Category: Chemistry Authors: Tags: FULL PAPER Source Type: research
Publication date: January 2018 Source:Journal of Molecular Liquids, Volume 249 Author(s): Foziah A. Al-Saif, Khuloud A. Alibrahim, Jawaher A. Alfurhood, Moamen S. Refat New six cobalt(II) complexes 1–6 with four generation of quinolone drugs (nalidixic acid (Nal), oxolonic acid (Oxo), pipemidic acid (Pip), lomefloxacin (Lom), pefloxacin mesylate (Pef) and levofloxacin (Lev)) have been synthesized in methanol medium, and the general formula was designed as [Co(L)2(Cl)2(H2O)2]·4H2O (L=Nal (1), Oxo (2), Pip (3), Lom (4), Pef (5), and Lev (6)). The Co(III) complexes were identified using micro–analytical, F...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 6 November 2017 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): P. Adwin Jose, J. Dhaveethu Raja, M. Sankarganesh, J. Rajesh In this work, we have synthesized pyrimidine derivatives of Schiff base ligand 2-(4,6-dimethoxypyrimidin-2-ylimino)methyl)-6-methoxyphenol (DPMM) stabilized copper nanoparticles (DPMM-CuNPs) and nickel nanoparticles (DPMM-NiNPs) by modified Brust-Schiffrin technique as two step phase transfer assisted method and confirmed by UV–Visible, SEM and TEM analysis. The free radical scavenging activity of DPMM, DPMM-CuNPs & DPMM-NiNPs with...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Publication date: Available online 2 November 2017 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohammad Tuhin Ali, Sheikh Tanzina Haque, Md. Lutful Kabir, Sohel Rana, Md. Enamul Haque Petroleum ether, ethyl acetate and methanol extracts of the stem bark of Albizia lebbeck and Acacia nilotica was investigated for antimicrobial, antioxidant and cytotoxicity assay. The powdered stem bark was extracted successively with petroleum ether, ethyl acetate and methanol solution. The crude extracts were subjected to antimicrobial, antioxidant and cytotoxicity assay by using disc diffusion method, DPPH and hyd...
Source: Bulletin of Faculty of Pharmacy, Cairo University - Category: Drugs & Pharmacology Source Type: research
Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
This article provides an overview of selected virulence factors that are known to suppress host immunity and enhance the infectivity of these fungi. PMID: 29102684 [PubMed - as supplied by publisher]
Source: Fungal Genetics and Biology - Category: Biology Authors: Tags: Fungal Genet Biol Source Type: research
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