Memory CD4 + T cell subsets in tumor draining lymph nodes of breast cancer patients: A focus on T stem cell memory cells

ConclusionOur data suggest that following long-term exposure to putative tumor antigens, TSCM cells proliferate to generate a pool of committed memory and effector T cells. As the tumor progresses, the immunosuppressive milieu induced by tumor cells may slow down the differentiation of CD45ROLow TCM cells to more functional sub-populations.

Source: Cellular Oncology - October 9, 2017 Category: Cancer & Oncology Source Type: research