Spontaneously Hypertensive (SHR) Rats Choose More Impulsively Than Wistar-Kyoto (WKY) Rats on a Delay Discounting Task.

This study used a concurrent-chains procedure to examine possible differences in impulsive choice between SHRs and control-normotensive Wistar Kyoto (WKY) rats. The aim was to extend the generality of findings showing regularities between the hyperbolic-decay model and the generalized matching law fitting delay discounting data from nonhuman animals. The objectives were to: (1) examine differences in impulsive choice between SHRs and WKYs; (2) add evidence suggesting that the SHR is a suitable model of ADHD; (3) demonstrate that concurrent-chains procedures requiring locomotion detect differences in impulsive choice between SHRs and WKYs; (4) support the idea that impulsivity in nonhuman animals increases with training. The initial link used two non-independent random interval schedules arranging entries to the terminal links, where one fixed-time (FT) schedule delayed 1-food pellet and the other FT 4-food pellets. The FT delaying the former was kept constant at 0.1s and that delaying the latter changed after every 10 food deliveries, defining six delay components (0.1, 5, 10, 20, 40, and 80s) presented in random order each session. Results showed that the SHRs choose more impulsively than the WKYs, adding to the body of evidence suggesting that the SHR may be a suitable model of ADHD. Both models of choice fitted the impulsive choices of the SHRs and WKYs well; positive correlations between estimates of parameters k and s suggested compatibility between models of choice show...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research