Drug Hypersensitivity and Desensitizations

Hypersensitivity to drugs has increased in the twenty-first century due to an explosion in new and targeted medications to address diseases through personalized and precision medicine. From 45 monoclonal antibodies in 2017, there will be 75 in 2020, with four US Food and Drug Administration approvals targeting allergic diseases in the last 6  months. Small molecules are the newest generation of drugs, and reactions to apparently poorly allergenic compounds are becoming more frequent. As I was working with the authors on their submissions for this issue, I was asked to consult for a pharmaceutical company whose star medication was found to have great efficacy against a rare and deadly cancer in early clinical trials, but several patients had presented unexpected hypotension and anaphylaxis, which raised concerns about public safety and potential clinical use.
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Tags: Preface Source Type: research