Conceptualizing Paralogous Stem ‐Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities

This article is protected by copyright. All rights reserved. Top panel depicts “paralogous” bone marrow stem‐cell niches (PBMNs), such as perivascular and endosteal surface (ES) niches for skeletal stem cells (SSCs) and hematopoietic stem cell (HSCs). These PBMNs are progressively altered, parallel niches of bone marrow at different developmental stages of bone marrow. A proposed dynamic Yin‐Yang niche between the periarteriolar and perisinusoidal interface (i.e., the AS interface) might underlie the coupling and uncoupling of PBMNs with their regenerative zones. Lower panel illustrates alterations of PBMNs based on analysis of transcriptional activities in three representative transgene reporters (i.e., Nes‐Cre, Nes‐GFP, and Lepr‐Cre) that are associated with the genes encoding nestin (Nes) and leptin receptors (Lepr). In vivo cell‐fate mapping at various PBMNs would aid in resolving existing controversies on bone marrow stem‐cell origins and identities.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research