Fungicides for crops: Worrying link to fungal drug resistance in UK, warns scientists

Aspergillus -- a common fungus that attacks the lungs and is found in soil and other organic matter -- has become resistant to life-saving drugs in parts of rural Yorkshire, researchers report. Although the link has been made before in the Netherlands, it’s the first time its been made in the UK between drug resistance in Aspergillus and fungicides used on crops. Experts warn their findings, now published, are significant and raise serious implications for transplant patients, those with leukemia and people who suffer from severe asthma.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Abstract The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in ...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Team of researchers changes microbes in koalas ’ guts in order to improve type of food they consumeScientists believe they have found a new weapon in the battle to save endangered species: faecal transplants. They say that by transferring faeces from the gut of one animal to another they could boost the health and viability of endangered creatures. In particular, they believe the prospects of saving the koala could be boosted this way.The idea of using faecal transplants as conservation weapons was highlighted this month at the American Society for Microbiology meeting in Atlanta, where scientists outlined experiment...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Endangered species Conservation Environment Animals Wildlife Science World news Source Type: news
Authors: Spiliopoulos S, Hergesell V, Wasler A, Dapunt O Abstract Due to the declining instances of organ donation, total artificial heart (TAH) therapy is of increasing importance for the management of end-stage biventricular heart failure. We introduce the currently most important established and novel TAH systems (SynCardia, CARMAT, ReinHeart, BiVACOR), report clinical outcomes and discuss technical requirements for the successful implementation of TAH therapy as an alternative to cardiac transplantation. PMID: 29902152 [PubMed - as supplied by publisher]
Source: Biomedizinische Technik/Biomedical Engineering - Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research
Authors: Cao H, Zhao X, Lu S, Wang Z Abstract The aim of the current study was to measure the expression of acetyl-N-Ser-Asp-Lys-Pro (ACSDKP) in patients with acute myeloid leukemia (AML) and the effect of prolyl oligopeptidase inhibitor (POPi) on the bone marrow stromal cells of these patients. Serum and bone marrow stromal cell samples were collected from 33 patients with AML admitted to Wuxi Second People's Hospital, Nanjing Medical University between September 2011 and August 2016. ACSDKP levels were measured using a highly specific competitive enzyme immunoassay (EIA). Bone marrow stromal cells were treated wi...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Zhang Y, Hu Y, Li X, Shi X, Xu F, Jia H Abstract The aim of the present study was to investigate the role of the limbal stem cells in corneal epithelial homeostasis in patients with peripheral corneal disease who received corneal transplantation surgery. This retrospective study enrolled 85 patients (85 eyes) with peripheral corneal lesion who underwent corneal transplantation at Department of Ophthalmology in First Hospital of Jilin University, Jilin, China. All patients during each follow-up period were examined for best corrected visual acuity, corneal reconstruction (assessed by slit-lamp biomicroscopy...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Cheng PK, Chen XL, Su XX, Su XJ, Hou CL Abstract Refractory ischemic ulcers that occur in patients with diabetes present a major clinical challenge. Embryonic artery cluster of differentiation 133+ cells (EACCs) may promote the healing of diabetic ulcers; however, the high glucose environment in the diabetic ulcers decreases the survival rate of transplanted EACCs and inhibit their biological function. Furthermore, microcirculation in diabetic ischemic ulcers is impaired, which inhibits the beneficial effect of EACCs. In the current study, the Sirt1 agonist SRT1720 was selected as a therapeutic drug and lo...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Wang S, Pan Y, Zhang Z Abstract The level of 25-hydroxyvitamin D [25-(OH)D] associated with inflammatory factors in children during an asthma attack was investigated. In total, 60 child patients, who were admitted and treated in the Affiliated Children's Hospital of Xuzhou Medical University from March 2015 to March 2017, during their asthma attacks, were selected as the observation group. The patients were divided into the high 25-(OH)D (n=28) and low 25-(OH)D (n=32) groups according to the median level of 25-(OH)D. A total of 30 healthy children were selected as the control group. Biochemical indexes, hu...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
CONCLUSIONS: Interactions between leukemia cells and the bone marrow niche influence hematopoiesis, leukemogenesis, and chemotherapy resistance in AML and require ongoing study. Understanding the mechanisms that underlie these interactions will help identify rational niche-targeting therapies to improve treatment outcomes in AML patients. PMID: 29902132 [PubMed - as supplied by publisher]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
We hypothesize that the reduced peak aerobic power (peak V˙O2) after heart transplantation is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (≤1 yr) exercise training is primarily due to favorable skeletal muscle adaptations. Furthermore, the increased peak V˙O2 with long-term (>2 yr) training is primarily mediated by cardiac (sympathetic) reinnervation.
Source: Exercise and Sport Sciences Reviews - Category: Sports Medicine Tags: Perspective for Progress Source Type: research
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 58-year-old man is evaluated in follow-up for idiopathic pulmonary fibrosis (IPF), which was diagnosed 2 years ago. He has cough and shortness of breath and now requires supplemental oxygen at rest. Previous evaluations have not identified any cause for his symptoms other than progressive IPF. He has participated in pulmonary rehabilitation and continues in a maintenance program. He is a lifelong nonsmoker. His medical history is otherwise unremarkable, and he takes no medications. On physical examinat...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Pulmonology Source Type: blogs
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