Fungicides for crops: Worrying link to fungal drug resistance in UK, warns scientists

Aspergillus -- a common fungus that attacks the lungs and is found in soil and other organic matter -- has become resistant to life-saving drugs in parts of rural Yorkshire, researchers report. Although the link has been made before in the Netherlands, it’s the first time its been made in the UK between drug resistance in Aspergillus and fungicides used on crops. Experts warn their findings, now published, are significant and raise serious implications for transplant patients, those with leukemia and people who suffer from severe asthma.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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In a heartwarming reunion, a 9-year-old celebrating his cancer remission has met the man who saved him.
Source: ABC News: Health - Category: Consumer Health News Tags: GMA Source Type: news
This study aims to check the feasibility of the KDPI for a Spanish population and its predictive ability of graft and patient survival. MATERIALS AND METHODS: Data from 2,734 kidney transplants carried out in Andalusia between January 2006 and December 2015 were studied. Cases were grouped by recipient age, categorised by KDPI quartile and both graft and patient survival were compared among groups. RESULTS: The KDPI accurately discriminated optimal organs from suboptimal or marginal ones. For adult recipients (aged: 18-59years) it presents a hazard ratio of 1.013 (P
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Jason Anderson, 48, of Ogden, Utah, was on dialysis for the last four years and told he would die without a kidney transplant until his wife's co-worker, Kingslee Teo, offered to donate.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(CNN) — In what researchers are calling “the largest genetic study ever performed” on varicose vein disease, a Stanford University School of Medicine study found a person’s height to be a significant risk factor for developing varicose veins. “We not only found an association between height and varicose veins, but the genetic studies we did showed a causal link,” said cardiologist and study author Dr. Nicholas Leeper, an associate professor of surgery and cardiovascular medicine at Stanford. “That suggests that the genes and pathways that drive human height are also likely to be ca...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Local TV Varicose Veins Source Type: news
Patients with severe asthma were more likely to have asthma attacks when they had one or more of 10 traits identified, compared with those with nonsevere disease, a study has found.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news
Authors: Yu J, Hu M, Chen W, Wen Z Abstract BACKGROUND The aim of this study was to compare the expression levels of mRNA of the B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) and the WW domain-containing oxidoreductase (WWOX) genes and their protein products in tissues from patients with liver cancer with normal liver tissues from patients without liver cancer. MATERIAL AND METHODS The liver cancer group (N=56) included patients with available tissue samples of histologically confirmed liver cancer. The control group (N=24) included histologically confirmed normal liver tissue samples. Im...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
(Natural News) Organ transplants are considered one of the greatest advances of modern medicine. It’s incredible to think that an organ that is no longer needed by one person can be placed into someone else’s body and give them a new lease on life. Of course, it’s also one of the riskiest medical procedures –...
Source: - Category: Consumer Health News Source Type: news
This study aimed to identify the risk factors associated with complications and/or graft failure in kidney transplant patients with sepsis. A total of 14,658 kidney transplant patients with sepsis, identified in the National Inpatient Sample (NIS) database (data from 2005-2014), were included in the study and classified into three groups: patients without complications or graft failure/dialysis (Group 1), patients with complications only (Group 2), and patients with complications and graft failure/dialysis (Group 3). Multinomial logistic regression analyses were conducted to evaluate factors associated with kidney transpla...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Uptake and metabolism of mizoribine, an immunosuppressant, in L5178Y-R mouse lymphoma cells in vitro and peripheral blood mononuclear cells of rats and kidney transplant recipients in vivo. Drug Metab Pharmacokinet. 2018 Aug 25;: Authors: Oda K, Mori N, Okumi M, Furusawa M, Ishiguro M, Inoue K, Shuto S, Unagami K, Ishida H, Tanabe K, Murakami T Abstract The cellular uptake of mizoribine (MZR), an immunosuppressant, and metabolism of MZR to MZR-5'- monophosphate (MZRP), an active metabolite, were evaluated in L5178Y-R mouse lymphoma cells and peripheral blood mononuclear cells (PBMCs) of rats ...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
Authors: Kumar S, Brown A, Tchounwou PB Abstract Trisenox (TX) has been used in the treatment of both de novo and relapsed acute promyelocytic leukemia (APL) patients. Using in vitro APL cell lines model in this research, we report on a new target of TX action through disruption of MDM2-DAXX-HAUSP complex, degradation of MDM2, and activation of p53 expression. TX-induced stress signal was transmitted by protein kinase (ATM &ATR) and phosphorylation of its downstream targets CHK1, CHK2, ATM, and ATR, respectively at the Ser 345, Thr68, Ser1981 and Ser 428 residues involved in complex disruption and p53 up-regula...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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