Impact of resveratrol on bone repair in rats exposed to cigarette smoke inhalation: histomorphometric and bone-related gene expression analysis

This study investigated the effect of resveratrol on bone healing and its influence on the gene expression of bone-related markers in rats exposed to cigarette smoke. Two calvarial defects were created in each of 60 rats, which were assigned equally (n=20) to three groups: (1) resveratrol (10mg/kg)+smoke exposure (SMK+RESV); (2) placebo+smoke exposure (SMK+PLA); or (3) placebo+no smoke exposure (NS+PLA). Substances were administered daily for 30days following surgery. Smoke inhalation was started 7days before surgery and continued for 30days after surgery.

Source: International Journal of Oral and Maxillofacial Surgery - September 16, 2017 Category: ENT & OMF Authors: F.C. Franck, B.B. Benatti, D.C. Andia, F.R. Cirano, R.C. Casarin, M.G. Corr êa, F.V. Ribeiro Tags: Research Paper Source Type: research