Computational and Mathematical Methods to Estimate the Basic Reproduction Number and Final Size for Single-Stage and Multistage Progression Disease Models for Zika with Preventative Measures.

We present new mathematical models that include the impact of using selected preventative measures such as insecticide treated nets (ITN) in controlling or ameliorating the spread of the Zika virus. For these models, we derive the basic reproduction number and sharp estimates for the final size relation. We first present a single-stage model which is later extended to a new multistage model for Zika that incorporates more realistic incubation stages for both the humans and vectors. For each of these models, we derive a basic reproduction number and a final size relation estimate. We observe that the basic reproduction number for the multistage model converges to expected values for a standard Zika epidemic model with fixed incubation periods in both hosts and vectors. Finally, we also perform several computational experiments to validate the theoretical results obtained in this work and study the influence of various parameters on the models. PMID: 28894473 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research

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June 18, 2018Is the World Health Organization reembracing its original principles?As the World Health Assembly (WHA) ended last month, I was left wondering: is this a new and improved World Health Organization (WHO), or is it simply becoming what its founders intended all along?Here are a few things that made this annual meeting of the WHO different from past years, and offer us some insight about how the organization might be evolving.A physical focus on noncommunicable diseasesThe day before WHA officially began, hundreds of participants and curious locals followed the WHO ’s new Director-General Dr. Tedros Adhanom...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Source Type: news
Abstract Zika virus (ZIKV) is a re-emerged human pathogen, belonging to a super serogroup with dengue virus. Infection of ZIKV can lead to severe congenital symptoms, such as microcephaly, in newborns and Guillain-Barré syndrome in adults. To date, no prophylactics and therapeutics are available. Flavivirus envelope (E) protein represents the major target for neutralizing antibodies, while antibody response is the key correlate of protection against ZIKV infection. A panel of monoclonal antibodies (MAbs) were found to neutralize ZIKV infection and some of them exhibited strong potential as antivirals. In th...
Source: Sub-Cellular Biochemistry - Category: Biochemistry Authors: Tags: Subcell Biochem Source Type: research
Zika virus (ZIKV) had spread rapidly in the past few years in southern hemisphere where dengue virus (DENV) had caused epidemic problems for over half a century. The high degree of cross-reactivity of Envelope...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
This study uses...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Social Sciences Source Type: research
Abstract The recent emergence and rapid spread of Zika virus in tropical regions of the Western Hemisphere took arbovirologists and public health officials by surprise, and the earlier transfers of West Nile and chikungunya viruses from the Old to the New World were also unexpected. These pandemics underscore the increasing threat of zoonotic arboviruses, especially those that are capable of entering into human-amplified, urban transmission cycles transmitted by Aedes aegypti and sometimes other Aedes (Stegomyia) spp. mosquitoes. This review serves as an introduction to a World Health Organization-sponsored confer...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
When Dr. Raj Panjabi talks about starting his nonprofit, Last Mile Health, he describes being motivated by both love and outrage. At nine years old, Panjabi had to flee his home in Liberia to escape civil war; he and his family relocated to the U.S. When Panjabi returned to his home country as a medical student, he discovered there were only 51 doctors left to serve the country’s four million people. As a result, many residents were dying from treatable conditions, especially in rural areas, simply because they lived too far away from doctors and hospitals. “We’ve kind of written these communities off as ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized community health workers Dr. Raj Panjabi ebola Health Care Last Mile Health medicine TIME 100 TIME 100 x WeWork Speaker Series Zika Source Type: news
This study explores the relation between exposure to Zika virus and the social representation of the epidemic. More specifically, one analyzes if increased exposure to the risk of Zika infection changes the characteristics of the web of meanings surrounding the epidemic. Between August and November of 2016, 150 interviews were conducted in the municipality of Governador Valadares, Minas Gerais State, Brazil. Based on the Free Words Association Technique, data on evocations related to the Zika virus were modeled by social network analysis, allowing the characterization of the web of meanings by level of exposure to the risk...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
by Julien Riou, Chiara Poletto, Pierre-Yves Bo ëlle Model-based epidemiological assessment is useful to support decision-making at the beginning of an emergingAedes-transmitted outbreak. However, early forecasts are generally unreliable as little information is available in the first few incidence data points. Here, we show how pastAedes-transmitted epidemics help improve these predictions. The approach was applied to the 2015 –2017 Zika virus epidemics in three islands of the French West Indies, with historical data including otherAedes-transmitted diseases (Chikungunya and Zika) in the same and other location...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Authors: Tay MYF, Vasudevan SG Abstract Dengue virus (DENV) replication occurs in virus-induced vesicles that contain the replication complex (RC) where viral RNA, viral proteins and host proteins participate in RNA-RNA, RNA-protein and protein-protein interactions to ensure viral genome synthesis. However, the details of the multitude of interactions involved in the biogenesis of the infectious virion are not fully understood. In this review, we will focus on the interaction between non-structural (NS) proteins NS3 and NS5, as well as their interactions with viral RNA and briefly also the interaction of NS5 with t...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Structures of Zika Virus E &NS1: Relations with Virus Infection and Host Immune Responses. Adv Exp Med Biol. 2018;1062:77-87 Authors: Shi Y, Dai L, Song H, Gao GF Abstract Zika virus (ZIKV), first discovered in the Zika forest in Uganda in 1947 was understudied until the recent explosive epidemic in several South American countries where it has become strongly associated with congenital birth defects leading to severe cranial malformations and neurological conditions. The increase in number of case of microcephaly in newborn children associated with ZIKV infection triggered the World Health Organiz...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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