A novel heterozygous mutation in the Birt-Hogg-Dub é Syndrome.
CONCLUSION: In patients presenting with bilateral multifocal renal tumors of oncocytic hybrid histology, Birt- Hogg-Dubé syndrome should be the first diagnosis in mind. The mutation found in this patient has not been previously described in the literature in the context of BHD. PMID: 28891800 [PubMed - in process]
ConclusionsTo increase the success of NK cell-based therapies of solid tumors, it is of great importance to promote their homing to the tumor site. In this study, we show that stable engineering of human primary NK cells to express a chemokine receptor thereby enhancing their migration is a promising strategy to improve anti-tumor responses following adoptive transfer of NK cells.
Conclusions Image-guided ablation can achieve local control for adrenal metastases < 5 cm.
Michael Needle, MD and Chief Medical Officer of AVEO Oncology goes over why and how Tivozanib (FOTIVDA(R)) was given approval in the European Union for the treatment of advanced renal cell carcinoma. Author: Cancer-News Added: 09/18/2017
The objective of the present study was to examine the role of SIRTs in RCC carcinogenesis and prognosis.
In conclusion, cellular immunotherapy and oncolytic therapy for cancer may be improved by the synergistic effects of lenvatinib and sensitized lymphocytes. In the present study, the inherent antineoplastic and immune stimulatory properties of the two agents were enhanced when used in combination, which may provide a basis for clinical treatment of patients with RCC. PMID: 28912872 [PubMed]
Between January 2013 and September 2015, 135 consecutive renal transplant patients were screened prospectively with ultrasound for renal cell carcinoma (RCC).
This study aims to determine the functional importance and underlying mechanism of miR‐122 in ccRCC metastasis. Here we demonstrate that the expression of miR‐122 increased in ccRCC tissues, and higher miR‐122 expression was found in ccRCC tissues with metastatic disease than in those without metastasis. The increased miR‐122 levels were associated with poor metastasis‐free survival in ccRCC patients with localized disease. Dicer was validated as a direct functional target of miR‐122. Overexpression of miR‐122 promoted migration and invasion of ccRCC cells in vitro and metastatic behavior of ccRCC cells in vi...
In this study, we explored its predictive value for treatment response and survival in metastatic renal-cell carcinoma (mRCC) patients.Experimental designA TKI cohort of 111 mRCC patients treated with sunitinib or sorafenib and a non-TKI cohort of 160 mRCC patients treated with interleukin-2 or interferon- α-based immunotherapy at a single institution were retrospectively enrolled. HLA class I expression and cytotoxic T lymphocyte (CTL) density was assessed by immunohistochemistry on tissue microarrays. Association between HLA class I and CTL was also assessed in the TCGA KIRC cohort.ResultsIn the TKI cohort, down-re...
To describe the course of disease of patients surgically treated for locally recurrent renal cell carcinoma (LRRCC) after nephrectomy and to identify potential predictive factors for long-term survival.