A novel heterozygous mutation in the Birt-Hogg-Dub é Syndrome.

CONCLUSION: In patients presenting with bilateral multifocal renal tumors of oncocytic hybrid histology, Birt- Hogg-Dubé syndrome should be the first diagnosis in mind. The mutation found in this patient has not been previously described in the literature in the context of BHD. PMID: 28891800 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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We report the case of a 51-year-old Thai female presented with right abdominal mass with pain and anemia. The radiographic findings showed ruptured renal mass. She underwent radical nephrectomy and the pathological report was malignant neuroendocrine tumor. Palliative chemotherapy was administered. The patient passed away three months after the operation. Renal neuroendocrine tumors are rare. Moreover, ruptured renal tumors are very rare. They are usually considered to be angiomyolipoma or renal cell carcinoma. Poor differentiation and rupture at presentation are aggressive features of tumors. To the best of our knowledge,...
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - Category: General Medicine Tags: J Med Assoc Thai Source Type: research
Publication date: Available online 23 June 2018 Source:European Urology Author(s): Rohit Mehra, Pankaj Vats, Xuhong Cao, Fengyun Su, Nicole D. Lee, Robert Lonigro, Kumpati Premkumar, Kiril Trpkov, Jesse K. McKenney, Saravana M. Dhanasekaran, Arul M. Chinnaiyan Renal cell carcinomas (RCC) with overlapping histomorphologic features poses diagnostic challenges. This is exemplified in RCCs with eosinophilic cytoplasm that include eosinophilic solid and cystic RCC (ESC RCC), RCCs in germline aberrations of tuberous sclerosis complex (TSC) genes mutated (TSC RCC) individuals, and other RCC subtypes. We used next-generation sequ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Pathology International, EarlyView.
Source: Pathology International - Category: Pathology Authors: Source Type: research
We report a unique case of using a C- EBUS scope for the diagnosis of pleural nodules and mediastinal lymph node metastasis in a man with metastatic renal cell carcinoma.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
This study aimed to evaluate conditional survival (CS) probabilities in patients with metastatic renal cell carcinoma (mRCC) who undergo first-line tyrosine kinase inhibitor (TKI) therapy and identify the predictors for CS over time.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
Journal of Cellular Biochemistry, EarlyView.
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Source Type: research
Clear cell renal cell carcinoma (ccRCC) represents the most common kidney cancer worldwide. Increased cell proliferation associated with abnormal microRNA (miRNA) regulation are hallmarks of carcinogenesis. Ankyrin repeat and single KH domain 1 (ANKHD1) is a highly conserved protein found to interact with core cancer pathways in Drosophila; however, its involvement in RCC is completely unexplored. Quantitative PCR studies coupled with large-scale genomics data sets demonstrated that ANKHD1 is significantly up-regulated in kidneys of RCC patients when compared with healthy controls. Cell cycle analysis revealed that ANKHD1 ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Gene Regulation Source Type: research
We present evidence for involvement of SP-A in RCC and suggest that increased SP-A expression in RCC is associated with favorable prognosis. PMID: 29932013 [PubMed - as supplied by publisher]
Source: Biotechnic and Histochemistry - Category: Research Authors: Tags: Biotech Histochem Source Type: research
CONCLUSIONS: High SOD2 expression can be predictive of a poor clinical outcome and be clinically useful in the follow-up of metastatic RCC. Therapeutics for metastatic RCCs require further improvement, such as supplementary administration of agents targeting mitochondrial SOD2. PMID: 29914010 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Renal cell carcinoma (RCC) represents 2-3% of all cancers in adults worldwide, and has an annual increase of around 2% in incidence during the past two decades [1]. Improved diagnostics have resulted in the increasing discovery of low stage renal tumors. Involvement of the venous system is a clinical characteristic of advanced RCC, which is observed in 4-10% of all RCC patients [2]. Radical nephrectomy with thrombectomy (RNTE) is the only curative therapeutic modality for these patients [3]. However, despite the aggressive resection was performed, the long-term survival of RCC with tumor thrombus (TT) remains poor compared to localized RCC.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Systematic or Meta-analysis Studies Source Type: research
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