Synthetic zwitterionic polysaccharides.

Synthetic zwitterionic polysaccharides. Curr Opin Chem Biol. 2017 Sep 06;40:95-101 Authors: Zhang Q, Overkleeft HS, van der Marel GA, Codée JD Abstract Zwitterionic polysaccharides (ZPSs) are a unique class of polysaccharides that are capable of eliciting a T-cell response after being processed by antigen presenting cells and presented on MHC II molecules. In addition, they have also been shown to be potent stimulators of the innate arm of the immune system. To unravel the molecular details of their remarkable immunological activity, various synthetic approaches to assemble fragments towards these polysaccharides have been reported. This review describes these efforts, illustrating the immense challenges presented by these inspiring structures. PMID: 28888143 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research