MiR ‐21‐mediated suppression of Smad7 induces TGFβ1 and can be inhibited by activation of Nrf2 in alcohol‐treated lung fibroblasts

ConclusionsAlcohol treatment increases TGFβ1 in fibroblasts, at least in part, through augmentation of miR‐21, which then inhibits Smad7 expression. These effects can be attenuated by activation of Nrf2 with SFP.This article is protected by copyright. All rights reserved.

Source: Alcoholism: Clinical and Experimental Research - September 9, 2017 Category: Addiction Authors: Lucian T. Marts, David E. Green, Stephen T. Mills, Tamara Murphy, Viranuj Sueblinvong Tags: Original Research Article Source Type: research