Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

Conclusions A combination of low ethanol and fatty acid that did not exert deleterious effects per se became toxic when oxidative metabolism was inhibited. The in vitro and in vivo damage was markedly inhibited by blockade of CEL, indicating the potential for development of specific therapy for treatment of alcoholic AP via inhibition of FAEE generation.

http://gut.bmj.com/cgi/content/short/63/8/1313?rss=1

Source: Gut - July 8, 2014 Category: Gastroenterology Authors: Huang, W., Booth, D. M., Cane, M. C., Chvanov, M., Javed, M. A., Elliott, V. L., Armstrong, J. A., Dingsdale, H., Cash, N., Li, Y., Greenhalf, W., Mukherjee, R., Kaphalia, B. S., Jaffar, M., Petersen, O. H., Tepikin, A. V., Sutton, R., Criddle, D. N. Tags: Pancreas and biliary tract, Pancreatitis, Open access Source Type: research