Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: a Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism

• PNH-type cells and HLA-allele lacking leukocytes were detected in patients with LGF• Two patients with PNH-type cells achieved transfusion independence after ATG therapy• Immune mechanisms similar to AA underlie half of the patients with donor-type LGF

Source: Biology of Blood and Marrow Transplantation - August 28, 2017 Category: Hematology Authors: Kana Maruyama, Nobuyuki Aotsuka, Yoshihisa Kumano, Naoko Sato, Naomi Kawashima, Yoshiyuki Onda, Hiroyuki Maruyama, Takamasa Katagiri, Yoshitaka Zaimoku, Noriharu Nakagawa, Kazuyoshi Hosomichi, Seishi Ogawa, Shinji Nakao Source Type: research