Testicular XX ( < b > < i > SRY < /i > < /b > -Negative) Disorder of Sex Development in Cat

In this study, we describe the first case of an XX (SRY-negative) DSD cat. The cat possesses a tortoiseshell coat associated with male-like external genitalia, including normal scrotum with 2 palpably normal testicles. Histological analysis confirmed the presence of the testes, and cytogenetic and genetic analyses showed a female karyotype associated with the absence of theSRY gene. Finally, sequencing of theRSPO1 gene revealed no mutation, and FISH analysis of theSOX9 locus did not reveal any large abnormalities.Sex Dev

Source: Sexual Development - August 25, 2017 Category: Biology Source Type: research