Mitochondrial regulation of hematopoietic stem cells

Hematopoietic stem cells (HSCs) are quiescent, can self renew, and generate all lineages of the hematopoietic system. Despite significant progress a coherent picture of how these mechanisms act in concert to regulate steady-state function and homeostatic responses of HSCs has not emerged yet.Furthermore, reliable renewal of HSCs in vitro has not been achieved, while there is overwhelming evidence that HSC self-renewal occurs in vivo. A particular gap is our understanding of the organellar cell biology of HSCs, which bridges transcriptional signatures to cellular functions.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research