New strategies for targeting leukemia stem cells

In this presentation, we will document our new strategies for the identification and ex vivo growth of primary leukemia stem cells. We will also show how we can exploit these newly developed methodologies to screen for compounds that specifically synergize to destroy leukemia stem cells. This includes cellular response to compounds and correlations of such responses to genetic anomalies found in each leukemia specimen. Redundancy of synthetic lethality between specimens appears to be predictable by companion tests which are being developed by our group.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research