The microenvironment induces collective migration in SDHB-silenced mouse pheochromocytoma spheroids

In this study, we demonstrated that SDHB silencing per se increases tumor cell migration/invasion and that microenvironment, as represented by CAFs, plays a pivotal role in enhancing collective migration/invasion in Pheo SDHB-silenced tumor cells, suggesting their role in increasing the tumor metastasizing potential.

Source: Endocrine-Related Cancer - August 22, 2017 Category: Endocrinology Authors: D'Antongiovanni, V., Martinelli, S., Richter, S., Canu, L., Guasti, D., Mello, T., Romagnoli, P., Pacak, K., Eisenhofer, G., Mannelli, M., Rapizzi, E. Tags: Research Source Type: research