Pilot validation of an individualised pharmacokinetic algorithm for protamine dosing after systemic heparinisation for cardiopulmonary bypass.
CONCLUSIONS: This study showed that an individualized pharmacokinetic algorithm for the reversal of heparin after cardiopulmonary bypass is feasible in comparison with a fixed dosing strategy and may reduce the protamine requirement following on-pump cardiac surgery.
PMID: 28820026 [PubMed - in process]
Source: Perfusion - Category: Cardiovascular & Thoracic Surgery Authors: Miles LF, Marchiori P, Falter F Tags: Perfusion Source Type: research
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