Changes in heparin dose response slope during cardiac surgery: possible result in inaccuracy in predicting heparin bolus dose requirement to achieve target ACT.

CONCLUSION: It can be hypothesized that the wide discrepancy in HDR slope versus heparin sensitivity may be explained by an inaccurate prediction of the plasma heparin level and/or the change in HDR of individual patients, depending on in vivo factors such as extravascular sequestration of heparin, decreased intrinsic antithrombin activity level and platelet count and/or activity.
PMID: 28820035 [PubMed - in process]

Source: Perfusion - August 20, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Ichikawa J, Mori T, Kodaka M, Nishiyama K, Ozaki M, Komori M Tags: Perfusion Source Type: research