Assessment of hepatitis B virus antibody titers in childhood cancer survivors

Conclusion: Childhood cancer survivors have high seronegative rates for HBV and the majority of the patients achieved HBsAb titer>  10mIU/ml with a single booster dose of HBV vaccine, which is worth further investigation and research. This study suggests revaccination against HBV post-chemotherapy treatment, as the recommended advice, especially in countries with a high prevalence of HBV infection.What is Known:•There is a variable prevalence of low HBsAb titers measured after the end of chemotherapy in childhood cancer survivors.•There are no universal guidelines for revaccination of these patients.What is New:•This research identified that 86% of childhood cancer survivors treated with standard chemotherapy were seronegative for HBV infection.•A single booster dose HBV vaccine was successful for the majority of patients (90%) to achieve HBsAb titers>10  mIU/ml.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research