Evaluation of Antihyperglycemic Property from Syzygium oleana (Magnoliopsida: Myrtaceae) Pericarp
This study was to find out scientific evidence that the methanolic extract of Syzygium oleana pericarp has an antihyperglycemic property to manage type 2 diabetes. Materials and Methods: The secondary-metabolites' profile of methanolic extract of S. oleana pericarp was screened by phytochemical analysis methods, its antioxidant property was judged with DPPH scheme and linked to the ascorbic acid at the wavelength of 517 nm and its IC50 value was determined based on the Log dose inhibition curve. The paired samples t-test was used to determine the difference of blood glucose level of Rattus norvegicus before and after treatment by utilizing SPSS software version 24. The treated extract at 100 and 200 mg kg1 b.wt., administered to the glucose-induced diabetic rat and compared to the metformin (65 mg kg1 b.wt.). Histopathological investigations performed the evidence that the extract could improve pancreatic β-cells by depresses necrosis of pancreatic β-cells in the islet cells based on one way ANOVA (p
In conclusion, SGLT2i reduced not only HbA1c, BW and BMI but also AHI significantly and therefore has potential as an effective treatment of OSAS. PMID: 29459554 [PubMed - as supplied by publisher]
The more often people worked nights, the more likely they were to have Type 2 diabetes.
Conclusion: The allele frequency of SLC22A1 gene rs628031 in Javanese-Indonesian population was almost the same as those found in Afro-American population as well as in other Asian populations. Similar results were obtained when the A allele frequency of SLC47A1 rs2289669 was compared to those in Chinese population. Further studies are recommended to examine the correlation between these polymorphisms and the variability of pharmacokinetic profiles as well as glycemic response to metformin and its adverse reactions.
Conclusion: PROVALID will provide information on incidence and progression of renal and cardiovascular disease and therapy in patients with type 2 diabetes mellitus in different European countries. Thus, in contrast to many other cohort studies we will be able to associate national clinical practise pattern with outcome in this highly vulnerable patient population.Kidney Blood Press Res 2018;43:181 –190
DIABETES type 2 symptoms can include feeling very thirsty, being very tired, or unexplained weight loss. But, you could lower your blood sugar by adding these supplements to your diet everyday, it ’s been revealed.
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Authors: Zhang Z, Wang J, Wang H Abstract Non-alcoholic fatty liver disease (NAFLD) is a form of clinical syndrome characterized by the fatty degeneration in liver histology and should be further investigated. The aim of the study was to investigate the effects of blood glucose, serum chemerin and insulin resistance on non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus to provide a basis for the prevention and treatment thereof. In total, 300 patients with type 2 diabetes mellitus treated and admitted into the Endocrinology Department of our hospital from June 2015 to June 2017 were...
This study sought to investigate any correlation between fat mass and obesity-associated gene (FTO) expression and the severity of type 2 diabetes mellitus (T2DM). In total 110 patients newly diagnosed with T2DM in the outpatient department of Yantai Yuhuangding Hospital between September 2016 and March 2017 were selected as study subjects and were divided into severe (58 cases) and mild groups (52 cases) according to T2DM severity. Patients in the severe group were followed up for 12 weeks. An additional 60 healthy individuals were selected to serve as the normal control group. Fasting plasma glucose (FPG), fasting insuli...
Conclusion MURs may positively influence medication adherence. This improved adherence shows a measurable decline in HbA1c levels.
Publication date: Available online 21 February 2018 Source:Revista Clínica Española (English Edition) Author(s): R. Gómez-Huelgas, F. Gómez Peralta, L. Rodríguez Mañas, F. Formiga, M. Puig Domingo, J.J. Mediavilla Bravo, C. Miranda, J. Ena The prevalence of type 2 diabetes mellitus (DM2) increases markedly with age. Antidiabetic treatment and the objectives of glycaemic control in elderly patients with DM2 should be individualized according to their biopsychosocial characteristics. In elderly patients for whom the benefits of intensive antidiabetic treatment are limited, the basic...