Evaluation of Antihyperglycemic Property from Syzygium oleana (Magnoliopsida: Myrtaceae) Pericarp
This study was to find out scientific evidence that the methanolic extract of Syzygium oleana pericarp has an antihyperglycemic property to manage type 2 diabetes. Materials and Methods: The secondary-metabolites' profile of methanolic extract of S. oleana pericarp was screened by phytochemical analysis methods, its antioxidant property was judged with DPPH scheme and linked to the ascorbic acid at the wavelength of 517 nm and its IC50 value was determined based on the Log dose inhibition curve. The paired samples t-test was used to determine the difference of blood glucose level of Rattus norvegicus before and after treatment by utilizing SPSS software version 24. The treated extract at 100 and 200 mg kg1 b.wt., administered to the glucose-induced diabetic rat and compared to the metformin (65 mg kg1 b.wt.). Histopathological investigations performed the evidence that the extract could improve pancreatic β-cells by depresses necrosis of pancreatic β-cells in the islet cells based on one way ANOVA (p
CONCLUSIONS: Based on clinical trial data, the present analysis suggests that IDegLira is associated with improved clinical outcomes and cost savings compared with treatment with insulin glargine U100 plus insulin aspart for patients with type 2 diabetes not achieving glycemic control on basal insulin in the US. Therefore, IDegLira is likely to be considered dominant (cost saving and more effective) and consequently highly cost-effective in the US setting. PMID: 30114954 [PubMed - as supplied by publisher]
Authors: Hay T Abstract The purpose of this study was to analyze the extent to which the 'thrifty gene hypothesis' remains embedded within regimes of Canadian health care. The thrifty gene hypothesis, formulated by the American geneticist and travelling scientist James V. Neel in 1962, proposed that Indigenous peoples were genetically predisposed to Type 2 diabetes due to the foodways of their ancestors. The hypothesis was functionally racist and based on what biological anthropologists now call 'the myth of forager food insecurity.' Importantly, Neel reconsidered his own hypothesis in 1982 before he ultimately rej...
(MedPage Today) -- This week's topics include vaccination in pregnant women and ASD; treating stroke outside the window; smoking, mortality, and weight gain; and five risk factors for death in type 2 diabetes.
ConclusionsOur findings provide a physiological explanation for the athlete’s paradox and reveal LD morphology and distribution as a major determinant of skeletal muscle insulin sensitivity.
In conclusion, the data identified the IRE1α-Xbp1 signaling pathway as an essential mediator that associates EX-4 with the intracellular mechanism that inhibits ER stress and activates Akt in order to regulate β cell survival. This may provide important evidence for the use of EX-4 in treatments for type 2 diabetes. PMID: 30112049 [PubMed]
Publication date: Available online 17 August 2018Source: Neuroscience LettersAuthor(s): Yingli Jing, Mingming Liu, Fan Bai, Di Li, Degang YangAbstractPatients with spinal cord injury (SCI) have an increased risk for developing type 2 diabetes. It is unknown whether the pancreatic-islet microvascular vasomotion is involved. We used female C57BL/6 mice and a 100-kilodyne T10 Infinite Horizons contusion SCI (or T10 laminectomy) to detect blood glucose and pancreatic-islet microvascular vasomotion. Blood glucose obtained from tail vein was detected using one Touch UltraEasy glucometer. Glucose tolerance test was performed by D...
Child health experts say the rise is "alarming" and more should be done to reduce obesity.
Publication date: Available online 17 August 2018Source: American Journal of Preventive MedicineAuthor(s): Tannaz Moin,, Julie A. Schmittdiel,, James H. Flory,, Jessica Yeh,, Andrew J. Karter,, Lydia E. Kruge,, Dean Schillinger,, Carol M. Mangione,, William H. Herman,, Elizabeth A. Walker,ContextPrediabetes is prevalent and significantly increases lifetime risk of progression to type 2 diabetes. This review summarizes the evidence surrounding metformin use for type 2 diabetes prevention.Evidence acquisitionArticles published between 1998 and 2017 examining metformin use for the primary indication of diabetes prevention ava...
We described the risk of major adverse cardiovascular events (MACE) and hypoglycemic in type 2 diabetic patients according to both HbA1c and FPG levels.MethodsWith the usage of databases of Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE), 1815 patients from 61 centers in China was identified and grouped according to the criterion value of HbA1c and FPG: Good glycemic control (HbA1c
ConclusionFor poorly controlled T2DM on DPP-4i-based OAD therapy, switching to single-dose liraglutide to enhance incretin signaling is as effective as dose-titrated basal IGlar, but significant BW reduction was only seen in the liraglutide group. These results suggest that enhancing incretin signaling with a single-dose injectable GLP-1 RA might be an alternative to dose-titrated basal insulin therapy in patients with T2DM poorly controlled with DPP-4i-based OAD therapy. These findings should be confirmed in a longer and larger trial.Trial RegistrationTrial Registry (UMIN-CTR) as UMIN000012224.