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Enter your pharmacy in PHE's campaign

To increase awareness of heart health and reduce the risk of heart attack and stroke, Public Health England (PHE) will be encouraging adults to complete the new online'One You' Heart Age Test
Source: Royal Pharmaceutical Society News - Category: Drugs & Pharmacology Source Type: news

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Two recent meta-analyses investigated the risks and benefits of heparin reversal by protamine after carotid endarterectomy (CEA).1,2 They found that heparin reversal with protamine reduces the risk for reoperation due to bleeding without an increased risk of stroke, myocardial infarction, or death. Yet, we would like to address the hemostatic and hemodynamic effects of protamine.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liège Acromegaly Survey (LAS) Database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The following results were obtained at diagnosis. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females ...
Source: Endocrine-Related Cancer - Category: Endocrinology Authors: Tags: Research Source Type: research
Reductions in cardiovascular (CV) outcomes in recently reported trials, along with the recent approval by the U.S. Food and Drug Administration of an additional indication for empagliflozin to reduce the risk of CV death in type 2 diabetes patients with evidence of CV disease, have renewed interest in CV outcome trials (CVOTs) of glucose-lowering drugs. Composite end points are a pragmatic necessity in CVOTs to ensure that sample size and duration of follow-up remain reasonable. Combining clinical outcomes into a composite end point increases the numbers of events ascertained and thus statistical power and precision. Histo...
Source: Diabetes Care - Category: Endocrinology Authors: Tags: Perspectives in Care Source Type: research
This study explored the prognostic value of these screening tests in patients with coronary artery disease (CAD). RESEARCH DESIGN AND METHODS FPG, 2h-PG, and HbA1c were used to screen 4,004 CAD patients without a history of diabetes (age 18–80 years) for dysglycemia. The prognostic value of these tests was studied after 2 years of follow-up. The primary end point included cardiovascular mortality, nonfatal myocardial infarction, stroke, or hospitalization for heart failure and a secondary end point of incident diabetes. RESULTS Complete information including all three glycemic parameters was available in 3,775 pati...
Source: Diabetes Care - Category: Endocrinology Authors: Tags: Epidemiology-Clinical-Diagnosis and Screening Cardiovascular and Metabolic Risk Source Type: research
Cardiovascular medicine is struggling with the new proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor drugs for lowering low-density lipoprotein cholesterol (LDL), not primarily because of efficacy concerns or safety issues, but because the price of these new agents exceeds $14  000 a year. While clinicians are seeking to understand how best to exploit the potential for enhanced protection these drugs may provide to patients at risk of atherosclerotic complications (such as myocardial infarction and stroke), payers are focused on constraining the use of these medications , recognizing that the pool of candid...
Source: JAMA - Category: General Medicine Source Type: research
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
CHOLESTEROL can cause heart disease, heart attack, and stroke, but may be lowered through statins. These drugs may also be used to fight infectious diseases, such as malaria and typhoid, according to new research.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractObjectives The study sought to evaluate the presence of a clinically relevant rebound phenomenon after dual antiplatelet therapy (DAPT) discontinuation in randomized trials. Background It is currently unknown whether clopidogrel discontinuation after short-term DAPT is associated with an early hazard of ischemic events. Methods The authors performed an individual participant data analysis and aggregate meta-analysis. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as the composite of cardiac death, myocardial infarction (MI), or stroke. Results The study included 11,473 ...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - Category: Cardiology Authors: Tags: Coronary: Focus on Antithrombotic Drugs Source Type: research
ConclusionsIn patient undergoing aortic valve interventions, no difference was seen between the use of bivalirudin and heparin as the procedural anticoagulant agent, except for a significant lower myocardial infarction events when bivalirudin was used. Further large randomized trials are needed to confirm current results.
Source: Journal of Interventional Cardiology - Category: Cardiology Authors: Tags: ORIGINAL INVESTIGATION Source Type: research
Conclusion: Bangladesh has a unique opportunity to address hypertension now in order to prevent thousands of premature deaths and to accrue substantial net economic benefits within 6years.
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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