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What is heart failure? Three signs YOU could be suffering with deadly condition

HEART failure means the heart is not pumping blood around the body effectively - and can occur after a heart attack.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Authors: Arrieta A, Blackwood EA, Glembotski CC Abstract Cardiac myocytes are the cells responsible for the robust ability of the heart to pump blood throughout the circulatory system. Cardiac myocytes grow in response to a variety of physiological and pathological conditions; this growth challenges endoplasmic reticulum-protein quality control (ER-PQC), a major feature of which includes the unfolded protein response (UPR). ER-PQC and the UPR in cardiac myocytes growing under physiological conditions, including normal development, exercise, and pregnancy, are sufficient to support hypertrophic growth of each cardia...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
(Representative image of multiple arterial revascularization) A Canadian study [1] published in JAMA Cardiology has shown lower long term mortality, repeat revascularization, myocardial infarction and heart failure in patients receiving multiple arterial grafts as compared to those single LIMA (left internal mammary artery) graft along with SVG (saphenous vein grafts). Of over twenty thousand patients with triple vessel or left main disease who underwent CABG (coronary artery bypass graft), about 5600 received multiple arterial grafts and around 14500 received LIMA graft along with SVG. Subgroup analyses showed t...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology CABG coronary artery bypass graft Coronary artery bypass grafting left main disease LIMA LITA RIMA RITA triple vessel disease Source Type: blogs
Abstract AimsTo determine whether baseline metabolic syndrome (MetS) modifies the effect of intensive blood pressure control on cardiovascular (CV) outcomes, and whether effects varied by race/ethnicity. Materials and MethodsWe performed post‐hoc analyses among Non‐Hispanic Black (NHB), Non‐Hispanic White (NHW), and Hispanic participants with and without MetS in the Systolic Blood Pressure Intervention Trial (SPRINT) randomized to a systolic blood pressure (SBP) target of less than 120 mm Hg (intensive group, N = 4544) or one less than 140 mm Hg (standard group, N = 4553). Me...
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AimsIn heart failure (HF) with reduced ejection fraction and sinus rhythm, heart rate reduction with ivabradine reduces the composite incidence of cardiovascular death and HF hospitalization. Methods and resultsIt is unclear whether the duration of HF prior to therapy independently affects outcomes and whether it modifies the effect of heart rate reduction. In SHIFT, 6505 patients with chronic HF (left ventricular ejection fraction of ≤35%), in sinus rhythm, heart rate of ≥70 b.p.m., treated with guideline‐recommended therapies, were randomized to placebo or ivabradine. Outcomes and the treatment effect of ivabradi...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
CONCLUSION: Post-trial follow-up revealed continued deleterious AF/AFL effects. The amlodipine (ALLHAT) and pravastatin (ALLHAT-LLT) treatment groups showed lower all-cause and non-CVD mortality compared to the chlorthalidone and usual-care groups, respectively. PMID: 28987246 [PubMed - in process]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Protecting the heart after an acute coronary syndrome is a key therapeutic goal to support cardiac recovery and prevent progression to heart failure. A potential strategy is to target cardiac glucose metabolism at the early stages after ischemia when glycolysis is critical for myocyte survival. Building on our discovery that high-density lipoprotein (HDL) modulates skeletal muscle glucose metabolism, we now demonstrate that a single dose of reconstituted HDL (rHDL) delivered after myocardial ischemia increases cardiac glucose uptake, reduces infarct size, and improves cardiac remodeling in association with enhanced functio...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
In conclusion, enhancement of cardiac βarr2 levels/signaling via cardiac-specific gene transfer augments cardiac function safely, that is, while attenuating post-MI remodeling. Thus, cardiac βarr2 gene transfer might be a novel, safe positive inotropic therapy for both acute and chronic post-MI heart failure.
Source: Hypertension - Category: Cardiology Authors: Tags: Basic Science Research, Cell Signaling/Signal Transduction, Mechanisms, Translational Studies, Heart Failure Original Articles Source Type: research
CONCLUSIONS: No evidence of a difference in total mortality and serious adverse events was found between treating to a lower or to a standard blood pressure target in people with hypertension and cardiovascular disease. This suggests no net health benefit from a lower systolic blood pressure target despite the small absolute reduction in total cardiovascular serious adverse events. There was very limited evidence on adverse events, which lead to high uncertainty. At present there is insufficient evidence to justify lower blood pressure targets (≤ 135/85 mmHg) in people with hypertension and established cardiovascular di...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
ConclusionsIn conclusion, the study indicates that, in very young subjects with chronic hypoxia-related alterations of the heart, signs of a heart failure in the other organs and a history of AAS abuse, death can be ascribed to progressive heart failure due to the direct apoptotic cardiac and endothelial changes produced by AAS.
Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
• The first characterization of patients admitted for heart failure in China is described.• Differences in the patient characteristics and treatments were identified in China compared to other registries.• A high prevalence of patients discharged from the hospital for heart failure did not rec eive target drug dosing.• Low systolic blood pressure, acute myocardial infarction, infection, right bundle branch block, and elevated total bilirubin and blood urea nitrogen were predictors of in-hospital mortality in Chinese patients with heart failure.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Clinical Investigation Source Type: research
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