What is heart failure? Three signs YOU could be suffering with deadly condition
HEART failure means the heart is not pumping blood around the body effectively - and can occur after a heart attack.
The Hospital Readmissions Reduction Program (HRRP) has been associated with substantial reductions in readmission within 30 days of discharge among fee-for-service Medicare beneficiaries aged ≥65 years who are hospitalized with acute myocardial infarction, heart failure, or pneumonia – the target population for this program.1,2 There have been suggestions that hospitals may have pursued reductions in readmissions through efforts mainly directed towards Medicare beneficiaries aged ≥ 65 years without pursuing systematic improvements in the care of patients.
Conclusion: The cardiogenic shock phenotype in ESHF was distinct from AMI, characterized by higher filling and pulmonary artery pressures, lower DO2, greater anaerobic metabolism but less severe metabolic acidosis.
Conclusions: Lower risk of posthospitalization mortality among blacks, relative to whites, may be associated with higher rate of hospitalizations and differences in unobserved patient acuity. Disparities for Hispanics and Asians, relative to whites, vary with the mortality measure used.
Conclusions: MSSP-participating hospitals showed slightly greater reductions in readmissions during postimplementation years for Medicare patients initially admitted for HF or pneumonia, compared with other hospitals.
This study aimed to investigate whether melatonin attenuates obesity-related HFpEF. Male mice were fed a high-fat diet (HFD) from weaning to 6 months of age to induce HFpEF. The mice were orally administered melatonin (50 mg/kg) by 3 weeks. Diastolic function was significantly improved by melatonin supplementation in mice fed an HFD. Melatonin attenuated obesity-induced myocardial oxidative stress and apoptosis and promoted the secretion of C1q/tumour necrosis factor-related protein 3 (CTRP3) by adipose tissue. And depletion of circulating CTRP3 largely abolished melatonin-mediated cardio-protection. Melatonin-mediate...
ConclusionsAdults with CKD and higher circulating GDF-15, Gal-3, and sST2 concentrations experienced greater mortality. Elevated GDF-15 concentration was also associated with an increased rate of heart failure. Further work is needed to elucidate the mechanisms linking these circulating biomarkers with CVD in patients with CKD.
The body's attempt to recover after a heart attack can lead to heart failure. But, researchers may now have found a different way to regenerate the heart.
Publication date: October 2018Source: Clinica Chimica Acta, Volume 485Author(s): Rong Yu, Xuebin Han, Xun Zhang, Yun Wang, Tong WangAbstractCorin is a type II transmembrane serine protease that is highly expressed in the heart and plays a physiological role in the activation of natriuretic peptides. Corin is expressed primarily in myocytes, and it can enter the circulation. Circulating soluble corin has been found to be associated with various cardiovascular diseases, such as hypertension, heart failure, myocardial infarction, preeclampsia, and stroke. All these findings indicate that circulating soluble corin has the pote...
This study demonstrates that the fabricated scaffold is capable of transmitting both mechanical and chemical cues that is native to myocardial tissue and supports efficient growth of the CPCs.
Publication date: Available online 20 May 2018Source: PeptidesAuthor(s): Takeshi Tokudome, Kentaro Otani, Mikiya Miyazato, Kenji KangawaAbstractGhrelin, a growth hormone–releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone–releasing and orexigenic activities by binding to specific receptors in the brain. Subsequent studies showed that ghrelin participates in the regulation of diverse processes, including energy balance, body weight maintenance, and glucose and fat metabolism, and demo...