Chronic lymphocytic leukemia cells are active participants in microenvironmental cross-talk.

Chronic lymphocytic leukemia cells are active participants in microenvironmental cross-talk. Haematologica. 2017 Aug 03;: Authors: van Attekum MH, Eldering E, Kater AP Abstract The importance of the tumor microenvironment in chronic lymphocytic leukemia is widely accepted. Yet, the understanding of the complex interplay between the various types of bystander cells and chronic lymphocytic leukemia cells is incomplete. Whereas numerous studies have indicated that bystander cells provide chronic lymphocytic leukemia-supportive functions, it has also become clear that chronic lymphocytic leukemia cells actively engage in the formation of a supportive tumor microenvironment by engaging in several cross-talk mechanisms. In this review, we describe how chronic lymphocytic leukemia cells participate in this interplay by inducing migration and tumor-supportive differentiation of bystander cells. Furthermore, chronic lymphocytic leukemia mediated alterations in the interactions between bystander cells are discussed. Upon bystander cell interaction, chronic lymphocytic leukemia cells secrete cytokines and chemokines such as migratory factors (chemokine (C-C motif) ligand 22 and chemokine (C-C motif) ligand 2, which results in further recruitment of T cells but also of monocyte-derived cells. Within the tumor microenvironment, chronic lymphocytic leukemia cells induce differentiation towards a tumor-supportive M2 phenotype of monocyte-derived ce...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research