COX2 induction: a mechanism of endocrine breast cancer resistance?

ConclusionOur results indicate that one of the pharmacological effects to aromatase inhibitors (e.g., exemestane) involves the activation of the inflammatory pathway via release of PGE2. Further in vitro mechanistic and in vivo translational studies designed to elucidate the role of this newly discovered effect are now warranted.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research